Three quantitative trait loci (QTLs) modifying fetal hemoglobin (HbF) levels have been identified, and these have been shown to have a predictive value of disease severity in 尾 thalassemia and sickle cell disease in diverse ethnic groups. One of the HbF QTLs which consists of a set of ...
DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding ...
(QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide ...
(QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide ...
globin (HBG2) gene promoter, and HbF levels, has been well documented in Tanzanian patients selected from the Muhimbili Sickle Cell Collaborative Program [6], in Dar-es-Salaam [7], and in African American SCD patients selected from the Cooperative Study of Sickle Cell Disease (CSSCD) [13]...
DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci USA. 2008;105(33):11869-11874.G Lettre,VG Sankaran,MAC Bezerra.DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin ...
SickleCellDiseaseHBS1L-MYBPolymorphismPolymeraseChainReactionObjective: Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with -thalassemia major, no significanThoria A. OmarEmad F. Abd-ElhalimRawhia H. EledelMohamed A. SolimanFatma S. EbeidOla H. Elshafey...
Sickle cell disease and β-thalassemia demonstrate a remarkable diversity in phenotypic severity, and the innate ability to produce fetal hemoglobin (HbF, α 2γ 2) is a major ameliorating factor in these β-hemoglobinopathies. HbF and F cells (denoted FC; subset of erythrocytes that contain ...
HMI-LNCRNA plays an important role in regulating HBG expression, and its downregulation can result in a significant increase in HbF. HMI-LNCRNA might be a potential therapeutic target for HbF induction treatment in sickle cell disease and 尾-thalassemia....
A major ameliorating factor in sickle cell disease and beta-thalassemia is the inherent ability to produce fetal hemoglobin (HbF, a2g2), a highly heritable trait. We have previously mapped a major quantitative trait locus (QTL) controlling HbF levels to an array of single nucleotide polymorphisms...