6b and c). Inflammation-associated profibrotic signals were inhibited by treatment with rFGF1ΔHBS (Fig. 6b and c). Furthermore, we found a significant reduction in the number of DHE-positive cells and reduced MDA content in renal tissues of rFGF1ΔHBS-treated AN mice, associated with elevat...
The db/db mouse model is a polygenic model that is caused by a mutation in the leptin receptor gene, which is not the primary genetic cause of type 2 diabetes in humans. Additionally, the db/db mouse model may not replicate all of the pathological changes seen in human DR, such as ...