HBsAgHBVPeginterferonPEG-IFNPeginterferon therapyHBeAg-positiveHBeAg-negativeHepatitis B surface antigenemia (HBsAg) is the hallmark of HBV infection. Serum levels of HBsAg appear to reflect the degree of immune control over the virus: lower levels signify a higher level of immune control. One year ...
We report a case series of three HBeAg positive and five HBeAg negative patients (7 males, mean age 50.6 +/- 14.6 years) with chronic HBV infection experiencing sero-conversion after treatment with entecavir (0.5 mg/day or 1 mg/day), initiated in 2007. Overall, the mean time to HBsAg cl...
227例正在接受NAs治疗患者),纳入、排除标准未涉及HBeAg状态[24],HBeAg阴性患者达到主要疗效终点的比例(停用Bepirovirsen后,HBsAg < 0.05 IU/ml且HBV DNA < 20 IU/ml持续至少24周)比HBeAg阳性患者略高(NAs初治患者:HBeAg阴性者14%,HBeA...
评估治疗后12周的安全性和随访48周的HBsAg水平。 结果,24名CHB患者接受VIR-2218治疗,包括18例HBeAg阴性和6例HBeAg阳性。经过24周随访,多数不良事件(AE)的严重程度为轻度,未发现导致治疗中断的AE,也未观察到安全性实验室参数的临床显著变化。...
从研究数据来看,这些NA经治达到2015年指南停药标准的慢乙肝患者中HBsAg < 1000 IU/mL的比例就达到43.9%,大多都是追求临床治愈的优势人群,可通过合理的抗病毒治疗获得HBsAg清除后再停药更为安全可靠(相关链接)。 参考文献: Xie Y, Li M, Ou X, et al. HBeAg-positive patients with HBsAg < 100 IU/mL an...
guideline of prevention and treatrnent for chronic hepatitis B:a 2019 update[J]. Chin J Hepatol, 2019, 27(12): 938-961. DOI: 10.3760/cma. [4] Lampertico P. Entecavir versus lamivudine for HBeAg positive and negative chronic hepatitis B[J]. J Hepatol, 2006, 45(3): 457-460. DOI:...
[2] Xie YX, Ou XJ, Zheng SJ, et al. HBeAg-positive patients with HBsAg<100 IU/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. AASLD2021, Abstracts (Poster 789). [3] Gielen V, Kendrick S, Pandey P, et al. Outcomes after nucle...
HBsAg level cut off value 4.7log10IU/ml predicted moderate to advance fibrosis (F≥2) with 92% sensitivity, 85% specificity & 91% negative predictive value. Lower HBsAg level might reflect the status of advanced liver fibrosis in HBeAg positive chronic hepatitis B subjects. 展开 ...
Inactive HBsAg carriers were defined as follows: (1) positive for HbsAg; (2) negative for hepatitis B e antigen (HBeAg), positive for antibody to ... B Lee,W Koh,M Choi,... - 《Chest》 被引量: 0发表: 2005年 乙型肝炎患者血清HBeAg和HBV-DNA载量与临床分型及病理分级分期的关系 目的探...
检 测生化学;乙肝五项;HBVDNA定量;肝组织HE染色,MASSON染色及网 状纤维染色,进行病理诊断;KnodellHAI评分,纤维化评分;肝组织免 疫组化半定量法检测HBsAg、HBcAg。结果临床诊断与病理诊断符合率 e+CHB组%,e-CHB组%;e-CHB组纤维化程度较e+CHB组重,纤维化评分 较高(P<)。e+CHB组HBVDNA载量明显高于e-CHB组...