镰刀细胞贫血症(sickle cell anemia)和β-地中海贫血(β-thalassemia)都是由于编码成人血红蛋白β亚基的HBB基因上出现突变而导致的遗传性贫血症。这些疾病患者可能终生需要接受输血或者其它疗法的治疗。已有研究表明,在成人中重新表达胎儿血红蛋白可以起到缓解贫血症状的作用。但是编码胎儿血红蛋白的基因在胎儿出生之后就停止...
Sickle cell diseaseIon Torrent PGMHBB geneOmanHemoglobinopathies, such as sickle cell disease (SCD) and beta-thalassemia major (TM), are severe diseases and the most common autosomal recessive condition worldwide and in particular in Oman. Early screening and diagnosis of carriers are the key ...
Get the HBB gene in an expression-ready vector for your molecular biology studies by ordering a HBB ORF clone.
The scientists say their method, which repairs the beta-globin gene (HBB), avoids gene therapy techniques that can introduce potentially harmful genes into cells. Researchers discover safe way to repair sickle cell disease genes In review, a point mutation in the HBB (beta hemoglobin) gene occurr...
HBB gene encodes hemoglobin beta chain. The hemoglobin chains, each with its own heme moiety, cooperate in binding and release of oxygen. Hemoglobin monomers have been found in blood and other tissues including macrophages, alveolar epithelial cells and brain. Defects in HBB have been linked to ...
HBB gene encodes hemoglobin beta chain. The hemoglobin chains, each with its own heme moiety, cooperate in binding and release of oxygen. Hemoglobin monomers have been found in blood and other tissues including macrophages, alveolar epithelial cells and brain. Defects in HBB have been linked to ...
Sickle cell disease: A general overview. Neth J Med, 2004, 62: 364–374 5 Orkin S H, Kazazian Jr H H, Antonarakis S E, et al. Abnormal RNA processing due to exon mutation of the E-globin gene. Nature, 1982, 300: 768–769 6 Rees D C, Styles L, Vichinsky E P, et ...
The sequences of ssODNs for gene correction are shown below. b Sanger sequencing chromatographs of the PCR amplicons of the wild-type HUDEP-2 and the HBB CD41-42 (-TCTT) mutant stable HUDEP-2 cell lines (HUDEP-2-CD41-42 M), with the homozygotes 4 bp ...
Prenatal molecular diagnosis of beta-thalassemia and sickle cell anemia in the Syrian population. Hemoglobin. 2014;38:390–3. Article CAS Google Scholar Murad H, Moasses F, Dabboul A, Mukhalalaty Y, Bakoor AO, Al-Achkar W, Jarjour RA. Geographical distribution of beta-globin gene ...
Gene ID 3043 保存 Store at -20°C. Avoid freeze / thaw cycles. 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 纯化方法 Affinity purification 亚型 IgG 免疫原 A synthetic peptide of human HBB 性状 液体 Public Immunogen Range A synthetic peptide of human HBB Subcellular Locat...