Hauser–Kraus annulation of sulfonylphthalides with simple conjugated nitroalkenes follows the expected pathway to furnish naphthoquinones in moderate yields. However, a strategic variation of this reaction by employing nitroalkenes bearing an additional nucleophilic site results in [4+4] annulation leading ...
ring closure reactions, annulation reactionsrearrangementsA Hauser—Kraus annulation of sulfonylphthalides with conjugated nitro alkenes furnishes naphthoquinones in moderate yields.doi:10.1002/chin.201648114Kumar, TarunSatam, NishikantNamboothiri, Irishi N. N....
Total synthesisHerein, we describe the first total synthesis of parvinaphthol B, a polyhydroxynaphthoate derived from the root of Pentas parvifolia which exhibits cytotoxic effects against the TNBC cell line. The key feature of the synthesis involves a Hauser-Kraus annulation to provide the poly...
Hauser–Kraus annulationNanaomycinγ-LactoneA formal total synthesis of nanaomycin D has been achieved. The strategy employed made use of a one-pot cyclisation–stereoselective reduction of a hydroxyketone to install the pyranonaphthalene moiety after execution of a Hauser–Kraus annulation using a ...
Hauser–Kraus annulationA double Hauser–Kraus annulation between biscyanophthalide 4 and the d-mannose derived enone 39 provides access to an advanced intermediate 54 that is an excellent scaffold to effect an enantioselective total synthesis of crisamicin A 1....
2-Aza-1-cyano-4-hydroxyanthraquinone azaanthraquinone via Kraus-Hauser phthalide annulation 2-alkyl-3-pyridinoneDe Kimpe, N
Synthesis of indenofurans, benzofurans and spiro-lactones via Hauser–Kraus annulation involving 1,6-addition of phthalide to quinone methides 1Pallabita Basu aNishikant Satam aIrishi N.N. Namboothiri a
A one-pot Hauser–Kraus annulation–methylation via reaction of a highly-substituted enone with a cyanophthalide was employed to construct the naphthalene framework. Other key steps include Sharpless asymmetric dihydroxylation of a (Z)-alkene and an HF-pyridine mediated double TBS deprotection-spiro...