Hormone priming in breast cancer: Oestrogen priming has a detrimental effect on response in oestrogen receptor-negative patientsdoi:10.1016/0959-8049(93)90029-FLesley Seymour and Karin Meyer and Werner R. BezwodaEuropean Journal of Cancer
GLP-1 drugs mimic the action of the natural GLP-1 hormone, which is produced in the gut in response to eating. GLP-1 normally functions to slow gastric emptying, increase insulin production, and increase satiety, that is, the feeling of fullness (for further details, see sidebar “More abo...
et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444(7120), 770–774 (2006). 13. Ben-Dov, I. Z. et al. The parathyroid is a target organ for FGF23 in rats. J. Clin. Invest. 117(12), 4003–4008 (2007). 14. Farrow, E. G. & White,...
Protein-restricted diets promote health and longevity in many species. While the precise components of a protein-restricted diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of pro
It was found that IDC-L patients had lower tumor grade and higher hormone receptor positive proportions than IDC patients. Moreover, IDC-L patients were younger and had a similar hormone receptor status compared with ILC patients. Kaplan-Meier plots showed that the breast cancer-specific survival...
c. The cellular receptor for testosterone in the target cells is defective. d. The male with th A nurse is caring for a client with prostate cancer who is being treated with a hormone therapy. What should the nurse monitor for in order to evaluate the effect of ...
Improvements in PTSD severity, from the initial evaluation to the conclusion of the treatment, were found to be associated with modifications in neural responses in specific regions related to affect and cognitive processing, for each task, within the PTSD sample. A comparison was made using data ...
Cell membrane/receptor/transporter endothelin receptor type A EDNRA 10 5.098 10.699 0.019 4q31.22 chemokine (CC motif) receptor 1 CCR1 18 2.101 5.845 0.019 3p21 interleukin 1 receptor, type I IL1R1 30 2.241 13.731 0.025 2q12 EPH receptor B2 EPHB2 34 1.670 7.033 0.025 1p36.1-p35 frizzled ...
An elevated proportion of poor prognostic hormone receptor (HR)-negative and HER2-positive breast cancers is often cited to account for the adverse outcomes in young patients15,16,17,18. However, several lines of evidence suggest that differences in intrinsic biologic subtypes—including estrogen rece...
Given the polyspecificity of the binding pocket, ABCB1 inhibition by conformational hindrance is likely a more effective strategy than targeting ABCB1’s polyspecific binding pocket. Structure and Function of ABCB1 NBDs ABCB1 contains two ATPase sites, each comprising a Walker A motif and a ...