The patients gargled with 2.5 g Hange‐Shashinto‐To mixed with tap water 3 times a day during and after chemoradiation period, prohibiting eating and drinking for 30 minutes after the gargling. Results: Two patients started gargling with Hange‐Shashin‐To after grade III...
All 4 of the patients who did not receive Hange-shashin-to experienced diarrhea above Grade 1 within 6 days of starting therapy. The rate of diarrhea differed significantly between the patients receiving and not receiving Hangeshashin- to. In conclusion, preventive administration of Hange-shashin-...
We attempted to characterize the antidiarrheal action of Hange-shashin-to (TJ-14), a kampo medicine, by comparing its action with that of loperamide. The oral administration of TJ-14 caused the dose-dependent suppression of castor oil-induced diarrhea at 250 to 1000 mg/kg. No significant repr...
corticosteroneCOX‐2active componentsThis study was designed to examine the relationship between the antidiarrhoeal effects of Hange-Shashin-To (TJ-14) and its active components. Oral treatment with TJ-14 at 1000mg/kg significantly inhibited castor oil-induced diarrhoea. Both the 50% methanol eluate...
Keywords: Hangeshashin-to (TJ-14); irinotecan; cancer chemotherapy; drug intolerance; supportive therapy; cohort study; clinical epidemiology; propensity score; inverse probability treatment weighting; instrumental variable 1. Introduction Irinotecan hydrochloride (CPT-11), a semisynthetic derivative of ...
Mori K, Kondo T, Kamiyama Y, Kano Y, Tominaga K (2003) Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 51: 403-406.Mori K,Kondo T,Kamiyama Y,et al.Preventive effect of Kampo ...