A ketone having at least one α-hydrogen atom is halogenated and hydroxylated to produce an α-hydroxyketone. Condensation of the α-hydroxyketone with an organocarbazate produces the corresponding carboorganooxyhydrazone which is cyclized to a dihydrooxadiazinone.George E. Niznik...
aA preferred overall synthesis involves the halogenation of an a.,.beta.-unsaturated aldehyde or ketone of the formula (I) 5## Y is a cyano group (i.e. --CN) or an aminocarbonyl group (i.e. H.sub.2), and R, R.sup.1, R.sup.2 and R.sup.3 are, independently, H organic ...
If you take a solution of an enantiomerically pure, optically active ketone like this one [(S)-2-methylcyclohexanone] add a few drops of strong acid and stir overnight, you’ll come back the next morning to find that its optical activity hascompletely disappeared.[Note 2–acetic acid isn’...
(•••) IN THE CHEMICAL LITERATURE The synthesis of five-membered lactones (cyclic esters) has been accomplished... Draw the mechanism for the following reaction:<IMAGE> (•••) When alkynes are treated with water and bromine a bromoketone is produced. Provide a plausible arrow-p...
a range of aryl-substituted cyclopentene and cycloheptene derivatives were all viable in this deconstructive functionalization to achieve products19–23in moderate to good yields. Variation of the size of the ring containing the double bond led to geminal diiodide ketone products bearing carbon chains ...
药物合成反应 (第三版 闻韧) 课后答案Chapter 1 Halogenation Reaction 《药物合成反应》（第三版） 闻韧主编 习题及答案 第一章 卤化反应习题及答案 1. 根据以下指定原料、试剂和反应条件，写出其合成反应的主要产物。(1)(CH 3)2NCH 2CH 2OH SOCl 2 (2)CuCl 2 4 (3)P, Br 2 o (4)CH 2CHCOOCH...
Abstract: Halogenation of cyclopropyl-methyl ketone (CPMK) is effected with at least one dihalo-triorganophosphorane of formula (R)3P(X)2 (I) at 80-130 deg C, where (I) is prepared in situ from a triorgano-phosphane oxide or sulphide of formula R)3P=A (II) and a halogenating agen...
HALOGENATION OF METHYL KETONEPURPOSE:The compounds III and IV [A is amino or substituted amino; COB is carboxy;R' is =C(CH3)2, =PR (R<4> is alkyl, etc.), e.etc,;OR<2> and OR<3> are an independent group or ketal-forming group bonded with the other group; Y is H or methoxy...
HALOGENATION OF METHYL KETONEPURPOSE:The compounds III and IV [A is amino or substituted amino; COB is carboxy;R' is =C(CH3)2, =PR (R<4> is alkyl, etc.), e.etc,;OR<2> and OR<3> are an independent group or ketal-forming group bonded with the other group; Y is H or methoxy...
HALOGENATION OF METHYL KETONEPURPOSE:The compounds III and IV [A is amino or substituted amino; COB is carboxy;R' is =C(CH3)2, =PR (R<4> is alkyl, etc.), e.etc,;OR<2> and OR<3> are an independent group or ketal-forming group bonded with the other group; Y is H or methoxy...