Hallmarks of response, resistance, and toxicity to immune checkpoint blockade (2) Articleshttps://doi.org/10.1038/s41929-021-00729-41 State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai, China. 2 Key Laboratory for...
Additionally, we are beginning to understand the impact of acute and cumulative exposures-both internal and external to the host (i.e., the exposome)-on host physiology and response to treatment. Together these represent the current day hallmarks of response, resistance, and toxicity to ICB. ...
However, responses to this form of therapy are not universal, and insights are clearly needed to identify optimal biomarkers of response and to combat mechanisms of therapeutic resistance. A working knowledge of the hallmarks of cancer yields insight into responses to immune checkpoint blockade, ...
(b-c) Heatmaps as in a showing the difference in average scores between tumors stratified by lymph node metastasis and therapy resistance, respectively. Significance levels were computed by two-sided t-test and adjusted by Benjamini-Hochberg correction. Exact p values are shown in Table S8. (...
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science 2021;371:602–9. 98. Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin J-M, Morrison RM, et al. Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients...
On the other hand, dysregulation of hepatic energy metabolism contributes to common age-related conditions such as insulin resistance, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) [4,5]. The Hallmarks of Aging impact directly on all the different types of liver cells: ...
Therapy resistance in cancer is often driven by a subpopulation of cells that are temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose mutational drivers remain largely unknown. We develop methodology to robustly
androgen independence and castration resistance can be considered as prostate cancer unique hallmarks7,8,22,23. In HPCHM, systems medicine based view of self sufficiency in growth signaling hallmark comprises a core network of 163 proteins with 468 physical interactions, 21 pathway based functional mo...
which can enable metastatic cell survival in changing microenvironments with dynamic metabolic demands. Mitophagy can also confer therapeutic resistance as demonstrated by Hu et al, who showed tumour cells can upregulate mitophagy mediators such as BNIP3 to adapt to hypoxia induced by anti-angiogenic ...
Recently, nine cellular and molecular hallmarks of ageing have been identified, which characterise the ageing process, and collectively, may be key determinants of the ageing trajectory. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient...