Meibohm B. Pharmacokinetics and half-life of protein therapeutics. In: Kontermann RE, ed. Therapeutic Proteins: Strategies to Modulate their Plasma Half-Lives. Weinheim: Wiley-VCH; 2012:23-38.Meibohm B. Pharmacokinetics and half-life of protein therapeutics. In: Kontermann RE, editor. ...
METHOD FOR PROLONGING PROTEIN HALF-LIFEThe present invention relates to a method for prolonging the half-life of a protein, comprising substituting at least one lysine residue present in an amino acid of the protein, or a protein with a prolonged half-life. A protein of the present invention,...
The aim of the present work was to investigate the origin and half-life of endogenous S100B protein reported by many investigators as a useful melanoma serum marker. Within cells, S100B protein exists in homo- or heterodimer form containing mainly Ca(++), having a substantial fraction bound ...
The TrpRS insufficiency causes impairment of protein biosynthesis. The deficiency in TrpRS and tryptophanyl-tRNA due to TrpRS gene mutations or TrpRS inhibition ultimately lead to neurodegeneration and intellectual disability. It appears that the extension of the half-life of tryptophan-free ...
Miracle of Miracles, We Have Half-Life 3 Although the animal data, molecular weight (about 868), and elimination half-life (about 26 hours) suggest embryo-fetal risk, the high plasma protein binding (99.9%) should limit the amount crossing the placenta. Novel drugs approved in 2016 CSTD col...
In past, computational methods for predicting half-life of proteins/peptides in blood and kidney cells/cell lines have been developed. For example, ProtParam is a tool that helps to estimate half-life of a protein stored in Swiss-Prot/TrEMBL or a user entered protein. The estimation of ...
Prolonged serum half-life of a recombinant fusion protein linking activated coagulation factor VII with albumin (FVIIa-FP) in different pre- clinical species. J Thromb Haemost 2011; 9(Suppl. 2): 385.Thomas, WeimerHubert J., MetznerStefan, Schulte. Recombinant Albumin Fusion Proteins. 2013:, ...
Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear. In this study, several proteins with extended half-lives were engi...
英英 网络释义 half-life n. 1. (放射性物质的)半衰期the time taken for the radioactivity of a substance to fall to half its original value 2. 半衰期the time taken for the concentration of a reactant to fall to half of its original value in a chemical reaction ...
A new strategy of peptide half-life extension has been evaluated. We investigated libraries of a small and very stable protein scaffold called Nanofitin, capable of high affinity for protein targets. We have identified Nanofitins targeting Human and mouse Serum Albumin, which could significantly im...