Half-life is defined as the time required for the concentration of a drug in blood or plasma to reduce to half of its initial value. It is a hybrid parameter, determined by clearance and volume of distribution, as demonstrated in Eq. (12). For an orally administered drug, a single daily...
The most important metabolites being 10-hydroxynortriptyline and nortriptyline in plasma and brain, respectively. 2. After six (every half-life) repeated IP administrations: (i) AMI kinetic parameters were unchanged; and (ii) amounts of metabolites were significantly increased and the levels of AMI...