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No difference in half-life of IgG2 light chain isotypes κ and λ in mice.Helga K. EinarsdottirNigel M. StapletonSicco ScherjonJan Terje AndersenTheo RispensC. Ellen van der SchootGestur Vidarsson
for IgG, 6 days for IgA, 5 days for IgM, 2-8 days for IgD, 1-5 days for IgE Therapeutics The time that a therapeutic agent remains in the circulation, which reflects its rate of metabolism and elimination of parent drug and metabolites in the urine and stool. See Effective half-life...
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Influence of the Isotype of the Light Chain on the Properties of IgG and -4, the isotype of the L chain influenced the rate of clearance in mice, with IgG2lambda having a shorter in vivo half-life than IgG2kappa. ... RF Montano,SL Morrison - 《Journal of Immunology》 被引量: 82发...
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc
Enhanced Circulation Half-life for Human IFNa2b and IgG Fc Fusion Protein人干扰素α2b和IgG Fc片段融合蛋白显著延长体内半衰期 Lei Wang,Jian He,Weihua Xiao,王磊,何剑,肖卫华 Keywords: 干扰素α2b,免疫球蛋白,融合蛋白,半衰期,毕赤酵母 Full-Text Cite this paper Add to My Lib Abstract: 重组人干扰...
has an increased (or decreased) in vivo half-life by virtue of the presence of a modified IgG constant domain (preferably from a human IgG), or FcRn-binding portion thereof (preferably the Fc or hinge-Fc domain) 来自 Google Patents 喜欢 0 阅读量: 27 ...
The context-sensitive half-time, rather than the terminal elimination half-life, has been proposed as a more clinically relevant measure of decreasing drug... A Kapila,PSA Glass,JR Jacobs,... - 《Anesthesiology》 被引量: 857发表: 1995年 Methods and compositions for prolonging elimination half-...