The timing mechanism of the hair cycle remains poorly understood. However, it has become increasingly clear that the telogen-to-anagen transition is controlled jointly by at least the bone morphogenic protein (BMP), WNT, fibroblast growth factor (FGF), and transforming growth factor (TGF)-尾 ...
Section of Skin). The hair follicle originates from the surface of the epidermis. Follicles that produce terminal hairs extend into the deep dermis and, sometimes, even the subcutis. Meanwhile,
Internal Root Sheath:Surrounding the hair, towards the base of the hair follicle, is the internal root sheath, which consists of keratinized cells from the hair matrix. The type of keratin here is softer than that of the hair and is the same as that found on the skin’s surface. This ...
Hair anatomy Thehair follicleis a complex, hormonally regulated structure with a cyclical growth pattern. Each follicle is formed through an interaction between dermal and epidermal components. In the pregerm stage, there is an accumulation ofbasal cellsand associated mesenchymal cells, which form the...
The hair follicle (HF) is a skin appendage providing physical barrier to protect mammals from external stimuli. HF has been attracting great interest as an object of developmental and stem cell research, however, little attention has been paid to HF in the light of immunology. Previous observatio...
2.1 Normal anatomy and physiology of hair follicle The hair is a part of the integumentary system as an ectodermic addendum present on the epidermal skin surface consisting of hair shaft and hair follicle (Fig. 2). The system offers both protective and touch reception for augmenting the functio...
The infundibulum is the funnel-shaped, uppermost epithelial segment of the hair follicle. Thus, as the infundibulum represents a major interface zone of mammalian skin epithelium with the environment and harbors a rich residential microflora, it is not surprising that this area is endowed with a sp...
2.3. Hair Follicle Anatomy 2.3. Hair Follicle Anatomy The hair follicle is a complex epithelial structure and is enclosed by an outer root sheath (ORS), whicThhheehlpasirtofoslluicplpeoisrtahcaoirmgprloewx tehp,iathnedliaanl sitnrunectrurroeoatnsdheiastehn(cIlRoSse),dabnyd afonlloouwtesrt...
Indeed, immune cells regulate hair follicle function [47,48] and drive inflammatory hair loss, notably AA [21,22]. There have been efforts to incorporate immune cells into 3D skin organotypics, either by embedding immune cells directly into the dermal layer and the insert membrane [87,88] ...
Hair follicle development in mouse pluripotent stem cell-derived skin organoids. Cell Rep. 22, 242–254 (2018). Article CAS PubMed PubMed Central Google Scholar Yang, R. et al. Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. Nat. Commun. 5, ...