In humans this results in permanent deafness, as mammals are largely unable to regenerate hair cells. In contrast, zebrafish robustly regenerate hair cells in the sensory lateral line and ear and recent gene expression and time-lapse analyses of cell behaviors at the single cell level have ...
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Identifying the mechanisms that regulate hair cell regeneration may contribute to developing treatments for hearing loss in humans (pages 11361139).doi:10.1038/nm1096-1082Rubel, Edwin W.Stone, Jennifer S.Nature MedicineRubel, E.W., Stone, J.S., 1996. Stimulating hair cell regeneration: on a ...
Sensory hair cells located in the organ of Corti are essential for cochlear mechanosensation. Their loss is irreversible in humans resulting in permanent hearing loss. The development of therapeutic interventions for hearing loss requires fundamental kno
Hair Cell Regeneration, Repair, and Protection 2024 pdf epub mobi 电子书 图书描述 Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of ...
Hair cell regeneration in the avian auditory epithelium Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other ... JS Stone,DA Cotanche - 《International Journal of Developmental Biology》 被引...
However, the resulting cells rarely adopt a hair cell fate. As with the cell cycle, our increased understanding of the factors that determine hair cell fate selection may allow us to overcome barriers to hair cell regeneration in mammals. 展开 ...
More work needs to be done before the method can be tested in humans, according to the researchers. "We need to establish the origins of the critical intrinsic properties of the newly induced hairs, such as their hair cycle kinetics, color, angle, positioning, and texture" said Dr. Jahoda...
hair cell regeneration. To further improve the results of these therapies, it is important to understand the mechanism of hair cell regeneration and the properties of the new hair cells that are derived from different stem cells. In this review, we introduce the field of stem cell regenerative ...