Haemoglobin E-beta thalassaemia (Hb E/p-thalassaemia) is a common cause of thalassaemia major in Southeast Asia. In Singapore, the prevalence of beta thalassaemia (beta-thalassaemia) trait is 0.9% and haemoglobin E (HbE) trait is 0.55% .' This is especially high in the Malay ethnic group....
Haemoglobin E β thalassaemia is the commonest form of severe thalassaemia in many Asian countries, but little is known about its natural history, the reasons for clinical diversity, or its management. We studied 109 Sri Lankan patients with the disorder over 5 years. 25 patients were not recei...
血紅素E疾病(HaemoglobinE(HbE))什么是血紅素E疾病?血紅素E疾病(HbE)是常見的遺傳疾病,血液中生成了一種不正常的血紅素蛋白。血紅素是血液中的一種蛋白,為我們的身體傳送氧氣。HbE是父母通過基因遺傳給孩子的。基因攜帶了人體特征的信息,比如眼睛的顏色、頭發的顏色和血紅素。HbE是通過遺傳獲得。HbE不會傳染。HbE不會...
β-thalassaemia is one of the most common genetic blood diseases worldwide with over 300 mutations in the HBB gene affecting red blood cell functions. Recently, advances in genome editing technology have provided a powerful tool for precise genetic corre
Medical Encyclopedia Wikipedia Related to haemoglobinopathy:thalassemia,Hemoglobinopathies haemoglobinopathy (ˌhiːməʊɡləʊbɪˈnɒpəθɪ; ˌhɛm-)or n (Pathology) any of various inherited diseases, including sickle-cell anaemia and thalassaemia, characterized by abnormal ...
Erythrocyte superoxide dismutase activities were measured in 45 subjects, 15 each of beta 0-thalassaemia/haemoglobin (Hb) E disease, Hb H disease, and norm... P Yenchitsomanus,P Wasi - 《Journal of Clinical Pathology》 被引量: 34发表: 1983年 Haemoglobin E and alpha-Thalassaemia. Wasi P,...
respectively. Truncation of either the C-terminal IDR or both IDRs, but not the N-terminal IDR alone, markedly suppressed the formation of cytoplasmic foci. An A139P mutation in the C-terminal IDR, a causal mutation linked to β-thalassaemia13, also significantly compromised foci formation in ...
Hydroxyurea is one of the earliest drugs that showed promise in the management of haemoglobinopathies that include β-thalassaemia and sickle cell disease. Despite this, many aspects of hydroxyurea are either unknown or understudied; specifically, its us
E Gimferrer,M Baiget,PD Darbre,H Lehmann 摘要: A case of haemoglobin Lepore is reported in a Spanish patient who has a sideropenic anaemia and possibly a thalassaemia trait. The carrier’s clinical and haematological data are described. The structural analysis of the haemoglobin showed ...
Chan LC, So JC, Chui DH. Comparison of haemoglobin H inclu- sion bodies with embryonic zeta globin in screening for alpha thalassaemia. J Clin Pathol. 1995;48:861-864.Lau YL, Chan LC, Chan YY, Ha SY, Yeung CY, Waye JS et al (1997) Prevalence and genotypes of alpha- and beta-...