摘要 [目的]分析人肺腺癌吉非替尼耐药细胞株H1975(epidermal growth factor receptor,EGFR基因双突变)和人肺腺癌吉非替尼敏感细胞株PC9(EGFR单突变)细胞株微小RNA(microRN...展开更多 [Purpose] To differentiate microRNA(miRNAs) profiles in EGFR double mutations cell line-H1975 versus EGFR single mutation ...
一 tinib had neither additive nor synergistic effect.Conclusion TQ combined with Gef itinib treatment dose not increase the cytotoxicity ofEGFR—L858R/T790M mutant H1975 cell line. 【Key words】 Thymoquinone;Gef itinib;Epider m al growth factor receptor;Mutation;Combined therapy 肺癌是男性发病率...
(P < 0.05).There were no difference in EGFR gene mutation between NCI-H1975 and its subpopulations.Conclusions NCI-H1975 were heterogeneous on proliferation ability and drug reactivity and its heterogeneity were associated with sensitivity and resistance of drug treatment.%目的 探讨人非小细胞肺癌NCI...
(P < 0.05).There were no difference in EGFR gene mutation between NCI-H1975 and its subpopulations.Conclusions NCI-H1975 were heterogeneous on proliferation ability and drug reactivity and its heterogeneity were associated with sensitivity and resistance of drug treatment.%目的 探讨人非小细胞肺癌NCI...
吉非替尼耐药细胞株NCI.H1975/Ge6tinibResistance的建立及耐药机制初探计:学位论文:41页表格:2个插图:5幅田丽敏指导教师:**教授申请学位级别:硕士学位专业名称:病理学与病理生理学论文提交日期:2012年4月论文答辩日期:2012年5月学位授予单位:大连医科大学学位授予日期:2012年6月评阅人:答辩委员会主席:独创性声明卿...
a human lung adenocarcinoma cell line with the T790M/L858R mutation in EGFR. We first assessed the anti-proliferative effects of gefitinib or WK88-1 in H1975 cells. The cells were treated with the indicated concentration of gefitinib or WK88-1 up to 72 h, and cell proliferation was determin...
EGFR T790M mutation and the underlying mechanism were explored.MTT assay was performed to detect the effect of gefitinib,NVP-BKM120,NVP-BKM120 plus 1μmol/L gefitinib on growth of H1975 cells.The distribution of cell cycle and apoptosis rate of H1975 cells were examined by using flow ...
phosphorylation of several proteins of the PI3K/AKT signaling pathway and the mRNA expression levels of HIF1-α, VEGF and MMP9 in the acquired gefitinib resistant cell line H1975 were investigated, and whether NVP-BKM120 can overcome the acquired resistance caused by the EGFR T790M mutation and...
EGFR T790M mutation and the underlying mechanism were explored.MTT assay was performed to detect the effect of gefitinib,NVP-BKM120,NVP-BKM120 plus 1μmol/L gefitinib on growth of H1975 cells.The distribution of cell cycle and apoptosis rate of H1975 cells were examined by using flow ...
Keywords: cordycepin; H1975 cell line; apoptosis; proliferation; EGFR 1. Introduction Lung cancer remains one of the most common types of cancer worldwide. In addition, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers, with a five-year survival rate in ...