为增强顺向跨单级示踪工具的标记强度和效率、缩短示踪时间、并降低其末端吸收,该团队靶向H129的gK基因,构建突变gK囊膜化的顺向跨单级示踪工具H129-dgK-G4。H129-dgK-G4展示了更高标记强度和示踪效率、更特异的顺向标记特性、缩短了...
H129-dgK-G4Labeling intensityMutant gK pseudotypingRetrograde labelingBackground:Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to...
该研究基于HSV-1 H129株进行多轮病毒遗传改造,研发出一个具有高标记强度、高示踪效率、顺向示踪特异性更强的顺向跨单级示踪工具H129-dgK-G4。 绘制大脑神经网络连接图谱对于解析大脑结构、揭示大脑功能具有重要意义。神经环路示踪病毒工具是解析大脑连接图谱最重要的工具。罗敏华课题组前期对HSV-1 H129株进行改造,...
该研究基于HSV-1 H129株进行多轮病毒遗传改造,研发出一个具有高标记强度、高示踪效率、顺向示踪特异性更强的顺向跨单级示踪工具H129-dgK-G4。 绘制大脑神经网络连接图谱对于解析大脑结构、揭示大脑功能具有重要意义。神经环路示踪病毒工具是解析大脑连接图谱最重要的工具。罗敏华课题组前期对HSV-1 H129株进行改造,...
为增强顺向跨单级示踪工具的标记强度和效率、缩短示踪时间、并降低其末端吸收,该团队靶向H129的gK基因,构建突变gK囊膜化的顺向跨单级示踪工具H129-dgK-G4。H129-dgK-G4展示了更高标记强度和示踪效率、更特异的顺向标记特性、缩短了...
(H129-dgK-G4) was reconstituted and propagatedinthe Vero cell expressing wildtype H129 gK (gKwt) or the mutant gK (gKmut, A40V, C82S, M223I, L224V, V309M), respectively.Then the obtained viral tracers of gKmutpseudotyped and gKwtcoated H129-dgK-G4 were tested in vitro and in ...
为增强顺向跨单级示踪工具的标记强度和效率、缩短示踪时间、并降低其末端吸收,该团队靶向H129的gK基因,构建突变gK囊膜化的顺向跨单级示踪工具H129-dgK-G4。H129-dgK-G4展示了更高标记强度和示踪效率、更特异的顺向标记特性、缩短了示踪时间(Mol Neurodegener. 2022. 17:6)。