4. 基于PD-L1表达分层的患者临床预后 PD-L1表达使用IHC检测(TPS/CPS),TMB 10~16 mut/Mb组中,PD-L1表达<1的比例更高,且没有PD-L1表达≥50的患者;而TMB≥16 mut/Mb组中,PD-L1(TPS,tumor proportion scores)表达<1,1~50,≥50三个亚组的ORR分别是33.3%(5/15),40.0%(2/5),50.0%(3/6);PD-L1(...
Quantification of protein expression in IHC is typically assessed with H-scores, calculated by a pathologist on a scale from 0 to 300 based on the intensity of carcinoma cells and their relative proportion.The subjectivity of the methodology is an inherent risk of inconsistency for inter- intra-...
the system could be used to allow pathologists to spare IHC staining and interpretation from more than 70% of the patients while retaining 100% sensitivity for PD-L1 expression in MA31.
除了质量保证外,该系统还可以使病理学家在保留对MA31中PD-L1表达100%灵敏度的同时,免除超过70%的患者的IHC染色和解释。 Fig. 4 | Low-prediction score cases classified positive. Tissue images of patients classified positive by the first pathologist and low-PS by the system. The BCCA-test patients are...
IHC staining (c) and IF staining (d) of CD31 and CD206 were performed on paraffin-embedded section of rat liver tissues. Scale bar = 100 μm. F Histological scores were analyzed based on Suzuki’s criteria. Data are mean ± SD, **P < 0.01 by one-way ANOVA followed ...
we confirmed the ASO distribution by IHC across multiple regions of the brain including cortex, striatum, thalamus as well as CA1, CA3 and dentate gyrus regions of the hippocampus (Suppl Fig.9A). Co-localization of the ASO with a human-specific nuclear marker confirmed that the ASO was inter...
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Clinical scoring after oculonasal (a) or intravenous (b) infection was calculated by dividing the sum of the arithmetic mean values of daily scores by 10 (the number of observation days). The PI and IVPI values for each virus ranged from 0 (avirulent) to 3 (highly virulent) and the ...
Therefore, bITH score was subsequently calculated by introducing a weight function φi to the SDI formula to assign higher scores for samples with more diverse and dispersed clonality relation- ship per the following formula: n bITH = − ϕi ∗ Piln(Pi) i=1 where Pi is the fraction ...
e, f PDXs with high or low HNF3γ expression in their primary HCC tumors indicated by IHC staining scores (details can be found in “Materials and methods”) were treated with sorafenib (30 mg/kg body weight) or vehicle for 28 days. Xenografted tumor growth was monitored, and the ...