Sections were immunostained with monoclonal antibodies reactive with both alpha and beta subunits of the H+/K+-ATPase (proton) pump. Specimens were reviewed for staining pattern and intensity. Results: Stomach parietal cells (known to produce gastric acid) exhibited strongly positive staining for ...
摘要: Examines the regulation of colonic hydrogen-potassium-adenosine triphosphatase (H-K-ATPase) in large intestine and kidney by dietary sodium (Na) and dietary potassium (K) depletion. Molecular mechanisms by which dietary sodium and potassium depletion enhance active potassium absorption....
X Jiang,E Suzaki,K Kataoka 摘要: Parietal cells in the rat oxyntic mucosa were analyzed by the immunofluorescence pattern of the proton pump. The adult rats were grouped into fasting (C), gastrin-treated (G), and ranitidine-treated (R) groups, gastric pH was measured, and the stomach was...
The H + /K + -ATPase of gastric parietal cells catalyzes acid secretion in the stomach. Regulation of this pump's function involves its targeting to an intracellular storage compartment, which fuses with the apical plasma membrane in response to secretagogue stimulation. The H + /K + -ATPase...
The gastric parietal cell H,K-ATPase mediates the secretion of acid by an energy dependent, electroneutral exchange of intracellular H+ against extracellular K+. Among the different known P-type ATPases, the α-subunits of the vertebrate H,K-ATPases and.
Forte JG and Chow DC (1993) Structural and functional significance of the gastric H,K-ATPase. In: Domschke W, Konturek S (eds) The Stomach. Springer-Verlag, Berlin, in press. Forte JG, Ganser AL, Ray TK (1976) The K+-stimulated ATPase from oxyntic glands of gastric mucosa. In: Kas...
Disclosed are multibinding compounds which inhibit H<+>/K<+>-ATPase, an enzyme which is involved in the control of acid secretion in the stomach. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an inhibitor...
The presence and distribution of gastric-type H(+)-K(+)-ATPase were investigated in the rat colon using a monoclonal antibody raised against hog gastric H(+)-K(+)-ATPase. Rat stomach was used as positive control. Rat kidney and ileum, in both of which H(+)-K(+)-ATPase has been re...
H+/K+-ATPase (Proton Pump) is responsible for acid production from parietal cells of stomach. Acid-related disorders are caused by uncontrolled activity of proton pumps. Inhibition of these proton pumps has been shown to be effective in the treatment of GERD (Gastro-oesophageal reflux disease)....
The gastric proton pump, H + ,K + -ATPase, exports H + in exchange for luminal K + to generate a highly acidic environment in the stomach, and is a main target for acid suppressants. Here, we report the three-dimensional structure of gastric H + ,K +...