Sign in to download full-size image Figure 21-11. Small petechiae in an individual with thrombocytopenia.(From Callen J, Jorizzo J, Bolognia J, et al: Dermatological Signs of Internal Disease. Saunders, Philadelphia, 2009, with permission.) Either form can be treated with plasmapheresis and ex...
Sign in to download full-size image Figure 4.13.The megakaryocyte - this shows part of a very large cell which will fragment between the deep invaginations to form the non-nucleated platelets. Platelets survive about 10 days; the normal turnover is around 35000/day. Two thirds of the platele...
Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. Use public database to scr
Molecular Biology of Cancer by F. Macdonald and C.H.J. FordSidransky, D.NATURE MEDICINE
A fine mesh was utilized, which consisted of 23989 elements and resulted in less than a 0.5% difference in Joule heating between the electrodes upon further refinements. Table 2 Parameter values for FEM simulation Full size table Following a time-harmonic analysis of the electric field distribution...
These data show that like hRev3, hRev7, presumably as a part of human Polζ, plays a role in UV-induced mutagenesis of human cells. To determine whether hRev7 is similarly involved in the tolerance of DNA damage induced by benzo[a]pyrene diol epoxide (BPDE), the reactive form of the...
Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacillus spp. being isolated from the oral cavi
Circular RNAs (circRNAs) have emerged as crucial regulators of human cancers. Glutaminolysis supplies cancer cells with adequate nitrogen and carbon to replenish the tricarboxylic acid cycle, contributing to the survival and progression of tumor cells. H
Full size image Self-renewal-associated oncogenic pathways regulated by H1.0 Fig. 5: A minority of Quisinostat-responsive genes are responsible for inhibiting cancer cell self-renewal. Full size image To confirm the GSEA results, we focused on the TGFβ pathway and the EMT process, because of...
In contrast to the full-length HNF3 protein, the N-terminal 181 amino acids and the central, winged helix DNA binding domain of HNF3 did not bind the core histones (Figure 5E, lanes 2 and 4, respectively). Most of the binding activity of the full-length HNF3 protein was contained in...