Granzyme B是一种天然杀伤细胞(NK细胞和CD8+ T细胞)和细胞毒性T淋巴细胞(CTL)中的重要效应分子。 GZMB基因在多种细胞类型中表达,主要包括以下几个细胞类型: 1.自然杀伤细胞(NK细胞):NK细胞是一种免疫细胞,对肿瘤细胞和病原体感染的细胞有杀伤作用。GZMB基因在NK细胞中表达,编码的Granzyme B可通过细胞接触和释放...
Regulatory T cellsCCR8Cytotoxic T cellsLung cancerCCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8 + Tregs and their interaction with CD8 + T cells in the tumor ...
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GzmBW/W CD8 T cells are unable to lyse MCMV infected cells.Christopher, E. AndoniouVivien R., SuttonMatthew, E. WikstromPeter, FlemingKevin, Y. T. ThiaAntony, Y. MatthewsDion, KaisermanIona, S. SchusterJerome, D. CoudertPreethi, Eldi...
CD8+ lymphocytesProgrammed cell death ligand-1Granzyme B (GZMB) is a serine protease produced by cytotoxic lymphocytes that reflects the activity of anti-tumor immune responses in tumor-infiltrating lymphocytes (TILs); however, the prognostic significance of GZMB+ TILs in lung adenocarcinoma is poorly...
Further investigation indicated that NK cells, but not CD8(+) T cells, were the major sources of GrzB, and miR-378, but not miR-27a* or miR-30e, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice ...
Further investigation indicated that NK cells, but not CD8(+) T cells, were the major sources of GrzB, and miR-378, but not miR-27a* or miR-30e, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice ...
2003. Detection of low-frequency antigen-specific IL-10-producing CD4(+) T cells via ELISPOT in PBMC: cognate vs. nonspecific production of the cytokine. J. Immunol. Methods. 279: 111-121.3. Kreher, C.R., et al. 2003. CD4+ and CD8+ cells in cryopreserved human PBMC maintain full ...
The article Tcf1 protects antitumor TCRengineered CD8+Tcells from GzmB mediated selfdestruction, writ ten by Brendan Zangari, Takemasa Tsuji, Junko Matsuzaki, Hemn Mohammadpour, Cheryl Eppolito, Sebastiano Battag lia, Fumito Ito, Thinle Chodon, Richard Koya, A. J. Robert McGray and Kunle ...
Correction to: Tcf1 protects antitumor TCRengineered CD8+ Tcells from GzmB mediated selfdestructiondoi:10.1007/s00262-022-03233-1Cancer Immunology, Immunotherapy -Zangari, BrendanDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, USA...