GW8510是一种经常在生化研究中使用的化合物,尤其是那些专注于细胞周期进程的研究。它作为细胞周期蛋白依赖性激酶2(CDK2)的特异性抑制剂,CDK2是一种调节细胞周期从G1期到S期过渡的关键酶。研究人员利用GW8510来了解细胞分裂的分子机制,并确定潜在的目标以干预不受控制的细胞增殖。它对CDK2的抑制作用使其在旨在评估...
GW8510 CAS号: 222036-17-1 英文名: GW8510 英文别名: GW-8510 (GW8510;4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide;4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benz...
GW8510是细胞周期蛋白激酶2(CDK2)的抑制剂,可预防和/或减少化学疗法的副作用(脱发,足pal综合征和粘膜炎)。 GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities. ...
别名:GW8510 纯度:99% 分子式:222036-17-1 产地:湖北 品牌:国产 用途:工业生产 英文名称:GW8510CAS号:222036-17-1分子式:C21H15N5O3S2分子量:449.51EINECS号:中文同义词:英文同义词:4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide...
GW8510 CAS号: 英文名: 4-[[(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOL[5,4-E]INDOL-8-YLIDENE)METHYL]AMINO]-N-(2-PYRIDYL)BENZENESULFONAMIDE 英文别名: GW8510;4-[[(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOL[5,4-E]INDOL-8-YLIDENE)METHYL]AMINO]-N-(2-PYRIDYL)BENZENESULFONAMIDE ...
GW8510OverviewDetailsRecommendedEncyclopediaUpdatetime:Jan 01 2022Company Information InvivoChem , , United States Member Since: 2023 Business Type: Manufacturerquick details Molecular Formula: C21H15N5O3S2 Cas NO.: 222036-17-1 Name: GW8510 Refractive index: 1.813...
本发明提供了GW8510在制备哺乳动物自然衰老时延长寿命、提高认知能力和/或提高肌肉能力和/或提高运动能力药物中的应用,通过体外机制研究显示,GW8510可以调控细胞周期相关蛋白p21,CDK家族基因的表达,进而改善自然衰老细胞系2BS及WI38的复制性衰老状态,还可以改善衰老细胞的线粒体功能;通过小鼠实验显示,GW8510可以延长正常衰...
The combination of GW8510 and gemcitabine produced a synergistic effect on killing LSCC cells. The synergism of the two agents was impeded by addition of autophagy inhibitors chloroquine (CQ) or bafilomycin A1 (Baf A1), or knockdown of the autophagy gene, Bcl-2-interacting protein 1 (BECN1)...
In addition, GW8510 induced autophagic cell death. In addition, the sensitivities of CRC cells to GW8510 were associated with the levels of RRM2 and endogenous autophagic flux. Taken together, our study indicates that GW8510 could be a potential anti-CRC agent through targeting RRM2. Cell Death...
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