Here we compare the composition and functional potential of the gut microbiome in COPD patients with those of healthy controls, using untargeted faecal metagenomics and metabolomics. We describe an altered gut microbiome and metabolome associated with the disease. Several strepotococci and members of t...
metabolomemicrobiomemicrobiotamonkeyScope Iron deficiency (ID) compromises the health of infants worldwide. Although readily treated with iron, concerns remain about the persistence of some effects. Metabolic and gut microbial consequences of infantile ID were investigated in juvenile monkeys after natural ...
The microbiome of different types of carrion and the fecal metabolome were also further explored in this study. The results not only provide new insights into the scavenging adaptation of the Himalayan Griffons but also give information which is crucial for the conservation of this species. ...
Perturbations to the infant gut microbiome during the first weeks to months of life affect growth, development and health. In particular, assembly of an altered intestinal microbiota during infant development results in an increased risk of immune and metabolic diseases that can persist into childhood...
Background:While the microbiome has an established role in asthma development, less is known about its contribution to morbidity in children with asthma. Objective:In this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we analyzed the gut microbiome and metabolome of ...
Both microbiome and metabolome have been associated with the host condition through either correlations or predictions [22], often in conjunction with additional meta-data, such as age, gender, or diet [24,25,26,27,28,29,30,31]. Such prediction typically requires ML models, including deep ne...
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice Manfei Zhou, Yichun Fan, Liuting Xu, Zheng Yu, Sizhe Wang, Huaisha Xu, Jiuping Zhang, Linwei ...
Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbiome and its functional metabolites in PNS is r
The microbiome has been associated with animal behavior across the Chordata phylum12and may be one mechanism impacting fear behavior. Several studies have found that administering probiotic species ofLactobacillus, Bifidobacterium, orBacteroidesyields anxiolytic effects in rodents13,14,15,16. In germ-free...
The gut microbiome is an ecosystem that involves complex interactions. Currently, our knowledge about the role of the gut microbiome in health and disease relies mainly on differential microbial abundance, and little is known about the role of microbial