Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longe
Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging.gut microbiotahealthy agingdiversitybeneficial bacteriaThe world population is aging, which poses a significant burden to the economy and health care system. As people age, so do ...
liarityshownbylong-livingindividuals.Longevity isacomplextraitinwhichgenetics,environment, andstochasticityconcurtodeterminethechance toreach100ormoreyearsofage[1].Becauseof itsimpactonhumanmetabolismandimmunology, thegutmicrobiomehasbeenproposedasa possibledeterminantofhealthyaging[2,3].Indeed, thepreservationofhos...
The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn ...
Centenarians are an excellent model to study the relationship between the gut microbiome and longevity. To characterize the gut microbiome signatures of aging, we conducted a cross-sectional investigation of 1,575 individuals (20–117 years) from Guangxi province of China, including 297 centenarians ...
4月2日,中南大学湘雅医院神经内科、国家老年疾病临床医学研究中心沈璐教授团队与湘雅医院皮肤病医院李吉教授团队合作在Gut Microbes(肠道微生物)(IF=12.2)以论著形式在线发表了题为“Integrated analysis of gut metabolome, microbiome, and ...
A microbiome-mediated conversion of UA precursors can be avoided by directly supplementing with UA. The gut microbiota and urolithin A Usually, gut health is related to lifespan and good health. One of the many functions of the stomach is to expertly digest food. There is mountin...
Combination of two complement methods, in-depth metagenomic sequencing and culturomics, provides deeper insights into the longevity-related gut microbiota. The uniquely enriched gut microbes in Hainan extreme decades population may help to promote health and longevity. npj Biofilms and Microbiomes (2022)...
The fungal component of the human gut microbiome, also known as the mycobiome, plays a vital role in intestinal ecology and human health. However, the overall structure of the gut mycobiome as well as the inter-individual variations in fungal composition remains largely unknown. In this study, ...
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut ...