The integrative recommendations for BRCA testing presented here aim to (1) identify individuals who may benefit from genetic counselling and risk-reducing strategies; (2) update germline and tumour-testing indications for PARPi-approved therapies; (3) provide testing recommendations for personalised manag...
Adherence to National Comprehensive Cancer Network Guidelines for BRCA testing among high risk breast Cancer patients: a retrospective chart review studyBreast cancerPhysician and Practice Characteristicsdoi:10.1186/s13053-020-00144-zPriyanka Bobbili
Testing for BRCA variants may impact cancer prevention or treatment decisions in patients at heightened risk of hereditary breast cancer [3]. One study assessing 220 breast cancer patients reported a significantly higher proportion of contralateral prophylactic mastectomy, which may positively impact surviva...
Genetic testing guidelines for breast cancer are out-of-date and miss nearly half of patients diagnosed with the malignancy, doctors found in a new analysis of who gets tested and who doesn't. Health insurance companies and government payers base how they reimburse patients for tests and procedur...
Only about 5% of women with breast cancer are found to carry a mutated BRCA gene. Studies have confirmed that women who carry these BRCA mutations have a high risk for development of breast cancer, about five times that of women who do not have BRCA gene alterations. Overall, around 12% ...
Testing for mutations like PIK3CA and BRCA is also recommended to assist treatment decision. Patients with locally advanced breast cancer have relatively high risk of developing distal metastasis and detailed staging evaluation including medical history, physical examination, laboratory testing, breast X-...
Who qualifies for BRCA testing? Overall,inheritedbreastcancerdisorders account for a small minority of breast cancers. Genes are the "messages" in each cell of the body that determine the ultimate design of our bodies. Genes can be damaged by the environment. Additionally, people can be born wi...
The BRCA1 and BRCA2 mutation carriers have a 6–12 times higher lifetime risk of developing breast cancer compared to non-carriers [26]. In the USA and Europe, contrast-enhanced breast MRI screening as an adjunct to mammography for BRCA1 and BRCA2 mutation carriers has been established [27...
GermlineBRCAMutation Rates in Latina Women Presenting for Gynecologic Oncology Care Patients qualifying for genetic testing in accordance with NCCN Guidelines version 1.2017 for breast and/or ovarian cancer genetic assessment were identified. ... JIY Hong - 《Gynecologic & Obstetric Investigation》 被引量...
EPV160/#618Global assessment of guidelines for BRCA1/2 genetic testing: call to action in health equity for women and families at risk for hereditary ovari... gynecological cancers remains a significant challenge worldwide. Since 2019, the International Gynecological Cancer Society has been offering...