Also, the level of DBCA in urine was within the first 24 h about five times higher than that of 3-PBA: The mean level of DBCA in 24-h total urine reached 58.3 (range: 42.2–86.7) μmol/mol creat, while that of 3-PBA only reached 11.9 (range 8.0–18.5) μmol/mol creat. ...
Oral bioavailability of bisphosphonates is low, around 1 % of the dose ingested, and is impaired by food, calcium, iron, coffee, tea and orange juice. Bisphosphonates are quickly cleared from plasma, about 50 % being deposited in bone and the remainder excreted in urine. Their half-life in...
DXA measurement is the preferable radiological technique for confirming or excluding a diagnosis of osteoporosis, provides a prediction of fracture risk, and is also used in patient monitoring. DXA is measured at the femoral neck (and/or total hip) and lumbar spine [53]. Osteoporosis is present...
development of albuminuria in patients, given that certain factors can interfere transiently with this evaluation (eg, exercise, infections, fever, uncontrolled diabetes, hypertension). The mean albumin excretion of three timed urine collections can be used to establish a diagnosis of albuminuria...
The first steps in evaluating for LN involves urinalysis (dipstick and sediment), blood analysis (serum creatinine), and determination of spot urine protein:creatinine ratio. These tests may reveal proteinuria or evidence of impaired glomerular filtration rate (GFR). If either proteinuria (...