有的可以增强小G蛋白的活性,如鸟苷酸交换因子(Guanine Nucleotide Exchange Factor, GEF)和鸟苷酸解离抑制因子(Guanine Nucleotide Dissociation Inhibitor, GDI),有的可以降低小G蛋白活性,如GTP酶活化蛋白(GTPase Activating Protein, GAP)。
Thaker, Y.R., Raab, M., Strebhardt, K.et al.GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.Nat Commun10, 4804 (2019). https://doi.org/10.1038/s41467-019-12544-4 ...
The establishment of cell polarity is a prerequisite for many developmental processes. However, how it is achieved during tip growth in plants remains elusive. Here, we show that the RHO OF PLANTs (ROPs), ROP GUANINE NUCLEOTIDE EXCHANGE FACTORs (RopGEFs), and ROP GTPASE-ACTIVATING PROTEINs (Rop...
A GTPase-activating protein (GAP) specific for Gα z was identified in brain, spleen, retina, platelet, C6 glioma cells, and several other tissues and cells. G z GAP from bovine brain is a membrane protein that is refractory to solubilization with most detergents but was solubilized with ...
英文名称: Human Rho GTPase Activating Protein 32ELISA Kit 用途: 科研实验 产地: 上海 品牌: 睿创 包装规格: 96T/48T 标记物: HRP标记物 样本: 血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法: 酶联免疫法 应用: 定性/定量/酶活检测 检测限: 详见说明书 货号: RC-P91283O 是否...
RasGAP (Ras GTPase Activating Protein, GAP) 供应商 MyBioSource 产品货号 MBS617721 产品报价 ￥询价/0.2mg ￥询价/5x0.2mg ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868 ...
Genetic evidence suggests that RGS proteins inhibit G protein–mediated signaling at the level of the receptor–G protein interaction or the G protein α subunit itself. We have found that two RGS family members, GAIP and RGS4, are GTPase-activating proteins (GAPs), accelerating the rate of ...
The Saccharomyces cerevisiae gene, RNA1, encodes a protein with extensive homology to the mammalian Ran/TC4 GTPase activating protein. Using indirect immunofluorescence microscopy, we have demonstrated that rna1-1 mutant cells are defective in nuclear import of several proteins. The same result is obt...
A domain that mediates protein–protein interactions and binds Pro-containing short amino acid motifs. This domain is frequently found in proteins involved in signalling, endocytosis and actin regulation. GAPs and GEFs (GTPase-activating proteins and guanine nucleotide exchange factors). GAPs promote ...
(a guanine nucleotide exchange factor [GEF])[4–6]; and a protein that stimulates the GTPase activity of ARF1 (a GTPase-activating protein [GAP])[7–9]. These regulatory proteins are conserved throughout evolution; both reside in the cytosol and need to be recruited to the site of ...