Abr and Bcr are multifunctional regulators of the Rho GTP- binding protein family. Proc. Natl. Acad. Sci. USA 92:10282-10286.Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM (1995). Abr and Bcr are multifunctional regulators of the Rho GTP-bind- ing protein ...
Mouse Rem Protein The deduced amino acid sequence of Rem is shown in Fig. 2. This cDNA predicts a protein of 297 amino acids with a calculated molecular size of 32,893 Da. A data base search was performed to determine the degree of homology of Rem with the RGK family and to identify ...
Regad F, Bardet C, Tremousaygue D, Moisan A, Lescure B, Axelos M: cDNA cloning and expression of anArabidopsisGTP-binding protein of the ARF family. FEBS Lett 316: 133–136 (1993). ArticlePubMedGoogle Scholar Reynolds TL, Raikhel NV: Targeting and trafficking of vacuolar proteins. In T...
Proteins belonging to the family regulate the and act as molecular switches in a number of signal pathways. C3 and CNF1 have opposite effects on thus representing useful tools for studies on , and .doi:10.1038/sj.cdd.4400412Fiorentini, Carla...
A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Members of the Mx protein family promote interferon-inducible resistance to viral infection in mammals and act by unknown mechanisms. We identified an Mx-l... JH Rot...
With six complete or nearly complete genomes of evolutionary distant organisms, it is now possible to start addressing the evolution of primary structure and function in the Rab protein family. Rab proteins form the largest family of the Ras superfamily of small GTP-binding proteins and regulate ...
The predicted amino acid sequence includes a guanine nucleotide-binding domain that is homologous with those of a family of antiviral factors, inducible by interferon and known as MX proteins, and with the product of the essential yeast vacuolar protein sorting gene VPS1. These relationships imply ...
When these molecules bind to transmembrane receptors, a signal is propagated to effector molecules by intracellular signal transducing proteins, many of which are members of the G-protein family. The superfamily of GTP-binding proteins consists of several families including translational factors, ...
Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38γ-dependent signaling pathway A novel branch of the Ras family, Rit, was recently identified. Rit exhibits a distinct C-terminus and effector domain, and does not activate mitogen...
It has been demonstrated that the signaling pathways involve protein tyrosine kinases and phosphatases (4), the Rho family of small guanosine triphosphate (GTP)-binding proteins (5), and the heterotrimeric GTP-binding proteins (G proteins) of the Gq family (6,7). The involvement of G proteins...