important intermediate in the transfer of chemical energy in living systems. GTP is the source of the guanosine found in RNA and deoxyguanosine triphosphate (dGTP) is the source of the deoxyguanosine in DNA, and thus guanine is intimately involved in the preservation and transfer of genetic ...
This chapter explores the hypothesis that GTP, possibly acting through high guanine nucleotide energy charge, acts to stimulate a wide variety of anabolic processes involved in growth and cell proliferation. It is, according to this view, a mediator of the pleiotropic response. There are five main...
a, Compound6(cyan) is attached to Cys 12 of K-Ras(G12C) and extends into an allosteric binding pocket beneath switch-II (blue), the S-IIP. The binding pocket in K-Ras (surface representation of the protein shown) fits6tightly and includes hydrophobic sub-pockets (dashed lines). An ...
1.A method of screening for a compound having an activity to inhibit the binding between a protein peptide thereof and a ligand or analog thereof which binds to the protein wherein said protein is selected from the group consisting of(i) a protein comprising the amino acid sequence of SEQ ...
Deoxy-GDP (dGDP) was used as a reactant in place of GDP or IDP because it discriminates against pyruvate kinase (PK), which is known to be high in insulin-secreting tissues (7). The reactions were performed in quadruplicate in 96-well plates with a 200-μl final volume containing 110...
Zinc oxide is a common chemical additive, widely used in plastics, silicate products, synthetic rubber, lubricating oil, paint coatings, ointment, adhesives, food, batteries, flame retardant and other products in the production. Zinc oxide has large b...
Br-6-28 High-Speed Lockstitch Sewing Machine US$165.00 / Piece Br-6-28 Sewing Machine Lockstitch Machine US$160.00 / Piece Compound Feed Cutting and Binding Lockstitch Sewing Machine with Big Table Br-1510d-Ae US$2,300.00-2,700.00 / Piece ...