Finally, Rheb proteins have been shown to be farnesylated and small molecule inhibitors of protein farnesyltransferase can block the ability of Rheb to activate the TOR/S6K signaling.doi:10.1016/j.cellsig.2004.03.019Paul-Joseph AspuriaFuyuhiko Tamanoi...
Human GTP-Binding Protein Rheb (RHEB) ELISA KitThis Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RHEB (hereafter termed "analyte") in ...
Rheb proteins represent a novel and unique family of the Ras superfamily GTP-binding proteins that is conserved from yeast to human. Biochemical studies es... PJ Aspuria,F Tamanoi - 《Cellular Signalling》 被引量: 295发表: 2004年 Nomenclature for the human Arf family of GTP-binding proteins:...
The RheB Activation Assay Kit is based on the configuration-specificmonoclonalantibody that specifically recognizes RheB-GTP, but not RheB-GDP. Given the high affinity of monoclonal antibodies to their antigens, the activation assay could be performed in a short time. This assay provides the reliabl...
实验显示,RalA(G23C)和Rap1A(G12C)在与SII口袋抑制剂的共价结合方面表现出不同的动力学特征。RalA(G23C)与MRTX1257或divarasib结合的速度较快,且具有较高的热稳定性。突变型Rap1A(G12C, L96F)与抑制剂的结合速度显著提高。其他GTP酶如Rit1和M-Ras也能被SII口袋抑制剂有效靶向,但Rheb的靶向效果较差。
实验显示,RalA(G23C)和Rap1A(G12C)在与SII口袋抑制剂的共价结合方面表现出不同的动力学特征。RalA(G23C)与MRTX1257或divarasib结合的速度较快,且具有较高的热稳定性。突变型Rap1A(G12C, L96F)与抑制剂的结合速度显著提高。其他GTP酶如Rit1和M-Ras也能被SII口袋抑制剂有效靶向,但Rheb的靶向效果较差。
其他GTP酶如Rit1和M-Ras也能被SII口袋抑制剂有效靶向,但Rheb的靶向效果较差。为了验证MRTX1257对RalA(G23C)的结合是否类似于对K-Ras(G12C),研究人员分析了RalA(G23C)、GDP和MRTX1257的复合物。结果显示,GDP和MRTX1257的结合显著提高了RalA(G2...
实验显示,RalA(G23C)和Rap1A(G12C)在与SII口袋抑制剂的共价结合方面表现出不同的动力学特征。RalA(G23C)与MRTX1257或divarasib结合的速度较快,且具有较高的热稳定性。突变型Rap1A(G12C, L96F)与抑制剂的结合速度显著提高。其他GTP酶如Rit1和M-Ras也能被SII口袋抑制剂有效靶向,但Rheb的靶向效果较差。
RHEB, CT (RHEB, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain) (MaxLight 650) Basic information More.. Product Name: RHEB, CT (RHEB, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain) (MaxLight 650) Synonyms: RHEB, CT (RHEB, RHEB2, GTP-binding protein...
and those of mRNAhighly homologous to a human putative Rab5-interactingprotein mRNA, tobe decreased.Expression levels of the genes were compared with those in UV-irradiated UVr-1 cells, using Northern blot analysis.Furthermore,afunctionalanalysisusingantisenseoli-gonucleotides for human Rheb mRNAwas ...