We focused on a set of genes whose protein products are implicated in chromatin structure alterations and epigenetic modifications (RAD21, DNMT1, HDAC1), erythroid-specific gene regulation (GATA1 and TAL1), or shown to interact with TFII-I (TAF15 and Elongin A; Figure 3A) (15). In ...
in order to gain deeper insights into the role ofGtf2iand its relevance to mitochondrial function, we explored the outcomes of a hemizygous neuronalGtf2ideletion. Our findings unveiled
39,40,41 Interestingly, chromatin immunoprecipitation studies demonstrated that Pik3r1, which encodes the 85 kDa regulatory subunit of PI3K, is a direct target of GTF2I.42 We therefore studied Bdnf and Pik3r1 mRNA levels in the hippocampus of mutant and WT mice, as possible markers of synaptic...
bronchial mucosa or glands. Currently, it is the most common malignant tumor in the world [1]. According to statistics, in 2015, lung cancer is the most important cause of death in cancer patients, and the incidences of lung cancer in Chinese men and women were 50.9 per ...