(2015) .The Association of GSTM1 Deletion Polymorphism with Lung Cancer Risk in Chinese Population: Evidence from an Updated Meta-analysis . scientific reports . 5 : 9392Yang H, Yang S, Liu J, Shao F, Wang H, Wang Y. The Association of GSTM1 Deletion Polymorphism with ...
Previous studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. However, the results remained controversial. The aim of this study was to clari
The GSTM1 gene encodes the GST-μ1 enzyme and has been mapped to chromosome 1p13.3. There are two variants of GSTM1 that can occur through a substitution and a deletion, respectively. The substitution polymorphism changes C-to-G at base position 534, resulting in a lysine-to-asparagine swit...
In this study, we evaluated the associations and interaction between GSTM1 deletion, smoking behaviour and the development of colorectal cancer. We performed a pooled analysis within the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). We selected six ...
关键词:肺癌;遗传易感性;谷胱苷肽S转移酶M1(GSTM1);谷胱苷肽S转移酶T1(GSTT1);P16蛋白RelationshipbetweendeletionofGSTM1,GSTT1genesandsusceptibilitytolungcancer YAOWu,WANGNa,WUYongjun,etal.DepartmentofLaborHealthandToxicology,SchoolofPublicHealth,ZhengzhouUniversity(Zhengzhou450052,China)Abstract:Objective To...
In most studies, GSTM1 deletion was associated with male factor infertility. Salehi et al. (26) reported the highest risk up to 3.22. For the null of GSTT1, although most of the studies found a positive association with male factor infertility, Polonikov et al. (24) reported that the ...
When GSTT1 or GSTM1 was the homozygous deletion genotype, no corresponding electrophoretic bands appeared. As a result of no PCR products, routine sequencing technology could not test the sequences of homozygous deletion genotypes. Samples with the genotypes present were selected to test (performed ...
(GSTT1);P16蛋白RelationshipbetweendeletionofGSTM1,GSTTIgenesandsusceptibilitytolungcanceryAO,ANG,肌,Yongjun,eta1.DepartmentofLaborHealthandToxicology,SchoolofPublicHealth,ZhengzhouUniversity(Zhengzhou450052,China)Abstract:ObjectiveTostudytherelationshipbetweenthedeletionofglutathioneStransfer&seM1(GSTM1),glu-ta...
The examined genetic polymorphisms concerned glutathione S-transferases M1 (GSTM1; gene deletion; 96 workers), T1 (GSTT1; gene deletion), P1 (GSTP1; Ile-->Val substitution at codon 104 or Ile-->Val at codon 104 and Val-->Ala at codon 113), and microsomal epoxide hydrolase (EPHX; ...
The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation...