Results The positive expression rate of TopoⅡα、GST-π、P-gp in ovarian carcinoma was significantly higher than in benign tumors and normal tissues, P 0.05. A significant relationship was shown between TopoⅡα、GST-π expression and pathologic grade as well as clinical stage, respectively, P...
Developmental stage- and tissue-specific expression of GST cluster To determine the developmental stage and tissue-specific expression of six GST genes in the GST cluster, we re-analyzed our previously published RNA-seq data from cotton bollworm61. After filtering by fastp, the clean reads were ma...
植物在生长过程中会面临各种各样的胁迫,为了自我保护,植物进化出了多种抵御胁迫的策略。植物谷胱甘肽-S-转移酶(glutathione-S-transferases,GSTs,EC2.5.1.18)可以催化亲核性的谷胱甘肽(glutathione,GSH)与各种亲电子外源化学物的结合反应,降低细胞体内活性氧(reactive oxygen species,ROS)水平,从而减轻非生物胁迫对植物的...
lipids in high fat diet fed Gsto1−/−mice was significantly less (p < 0.001) than that occurring in their wildtype counterparts. Histological examination of the abdominal adipose tissue revealed increased inflammation in wild-type mice compared withGsto1−/−mice (Fig.4e,f). Further...
Renal tissue has a high metabolic activity and oxygen demand, leading to enhanced exogenous toxic or mutagenic metabolites and endogenous formations of reactive oxidants metabolites. Generally speaking, the GSTM1 enzyme catalyzes the binding of these metabolites to glutathione and the subsequent conversion...
stresses in viscoelastic materials to strain rate. Higherthan anticipated stresses lead to increased movement of tissue and components (through bending and other types of deformation) during firing. These motions can havea negative impact on outcomes leading to the need foradditional (and unnecessary)...
(χ2 was 6.91 and 3.14,P0.05),while the expression rate of TopoⅡ(45.3%,38/84)in colorectal carcinoma was lower,χ2=0.382,P0.05.The expression of P-gp was associated with clinical stage of tumor.The expression rate of P-gp on high clinical stage was 86.7%(39/45)and higher than ...
The DEGs were analyzed based on an algorithm as previously described62. The P-value corresponds to a differential gene expression test in which False Discovery Rate (FDR) was used to determine the threshold of the P-value in multiple tests. The Cluster 3.063 was used to the clustering ...
The article explains why Canada started where it did with respect to value added taxation and the constraints imposed by this starting point on future developments. The article also discusses three aspects of Canada's experience: why Canada introduced the GST at an unusually low rate and recently...
on-a-Chip in Cell and Tissue CulturesA Vertebrate Model for Human Molecular GeneticsABC Transporters: From Basic Functions to DiseasesActin-Myosin Cytoskeleton Regulation and Function Series 2Adaptation of Oral Tissue and Bone Remodeling to Systemic ImbalancesAdding New Pieces in the Osteopontin Puzzle...