We recently identified a novel γ-secretase modulator, GSM-10h, which effectively lowers Aβ42 production in cells and in amyloid precursor protein transgenic mice.Here, we describe the in vivo characterization of GSM-10h in a model of endogenous Aβ production.Rats were administered orally with ...
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There is also a role for hypoxic training during the rehabilitation process, providing a new stimulus for adaptation and providing a means of maintaining fitness whilst injured. At room temperature, connected to the power supply, can extract continuously high purity oxygen and di...