GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of...
Notably, rapamycin down-regulated GSK-3b Ser9 phosphorylation with...Jessica Dal ColRiccardo DolcettiCell CycleDal Col J, Dolcetti R (2008) GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in ...
Recognizes phospho-GSK-3β (Ser9). Molecular Weight: 47 kDa Immunogen: Peptide corresponding to amino acid region encompassing the human and rat phospho-GSK-3β (Ser9). Modifications: Phosphorylation Isotype: IgG Species Reactivity: Human Rat Quality Assurance: Routinely evaluated by immunoblot. Pur...
kinase and Akt mediated cell survival pathways,and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3 and Ser9 of GSK-3B. GSK-3 has also been implicated in alzheimer’s disease. Six Tau protein isoforms have been identified,all of which are phosphorylated by ...
(GSK3-beta) via its C-terminus domain. Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3-beta.Subcellular Location : Cytoplasm, cytoskeleton, centrosome.Tissue Specificity : Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than...
To date, phosphorylation at Ser9 by Akt is the best-characterized mechanism for the inhibition of GSK3β activity. GSK3β is phosphorylated at S389 in vivo by p38 MAPK and that this alternative regulatory mechanism of GSK3β is tissue-specific(PMID:18451303). 实验方案 Product Specific ...
GSK3α activity is mainly regulated via phosphorylation at Ser21 (inhibition) and Tyr279 (activation), whereas in GSK3β the corresponding amino acidic residues are Ser9 and Tyr216 [15,16]. The phosphorylated Ser residues of GSK3 act as pseudosubstrates that block the substratebinding siteand...
While Ser9 phosphorylation of GSK3b is ubiquitous, phosphorylation of GSK3b Ser389 occurs predominately in the thymus18. To determine whether phosphorylation of Ser389 on GSK3b was regulated during T-cell development, we examined phospho- Ser389 GSK3b in DN and double positive (DP) thymocytes ...
To the best of our knowledge, this is the first report of GSK3B- mediated ULK1 phosphorylation. Phosphorylation of these sites was important for the interaction of ULK1 with GABARAPL1 and MAP1LC3B. Furthermore, a marked increase in the phosphorylation of ULK1 on these resi- dues was observed ...
GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of...