mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta- catenin signaling. Cell. 2009;136(6):1017-1031.Mao Y, Ge X, Frank CL, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin ...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
2.上颚 β-catenin介导的Wnt信号通路涉及各种组织和器官的发育,包括颅面结构[5]。在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小...
Cat No. 22104-1-AP Publications(368) Host / Isotype Rabbit / IgG Reactivity human, mouse, rat and More (5) Applications WB, IHC, IF/ICC, IP, ELISA and More (3) Synonyms GSK3 beta, GSK3A B, GSK-3 beta, GSK 3 beta, EC:2.7.11.26 Formulation: PBS and Azide PBS and Azide...
(mGSK3B) existed where exons 8 and 9 were deleted. The mGSK3Bisoformlacked the ability to bindAxinand FRAT and thus the variant kinase was ineffective in phosphorylating beta-catenin suggesting a key role for this mutant kinase in CML biology (Abrahamsson et al., 2009). Supporting this ...
humanWB Environ Toxicol Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway. humanWB,CoIP J Clin Lab Anal Circular RNA circβ-catenin aggravates the malignant phenotype of non-small-cell lung cancer via encoding a peptide. ...
在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小鼠看起来正常且有生育能力,但通过Gsk3b+/-小鼠之间的杂交获得的Gsk3b-/-小鼠表现出完全的腭裂缺陷并在出生后24小时内死亡。为了确定Gsk-3β在腭发生过程中的...
Cat No.15113-1-AP Freight/Packing:-- Country/Region Please contact our China branch Proteintech Guarantee Request bulk or custom quote humanWB The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway. ...
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta- catenin signaling. Cell 2009;136:1017–1031. 32. Le Bacquer O, Shu L, Marchand M, et al. TCF7L2 splice variants have distinct effects on {beta}-cell turnover and function. Hum Mol ...