TNF在小鼠BMM中诱导细胞焦亡,其特征是GSDME-FL和GSDME-N表达增加以及PI阳性细胞数量增加。这些结果表明,作为RA发病机制的关键因素,TNF通过激活caspase 3/GSDME 途径促进巨噬细胞焦亡的诱导。 图3. 肿瘤坏死因子(TNF)通过体外激活caspase 3/GSDME通路诱导巨噬细胞焦亡 05 抑制caspase 3/GSDME途径后减少TNF诱导的巨噬细...
Fig. 6: Gsdme−/−, Casp3−/− and Ksp-cre Casp3fl/fl mice displayed a reduction of renal tubulointerstitial inflammation post-UUO. From: GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy A, C Representative images of kidney tissues stained with the ...