信息来源:Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein Int. J. Mol. Sci. 2024, 25(7), 3734; doi.org/10.3390/ijms250 Submission received: 6 February 2024 / Revised: 8 March 2024 / Accepted: 22 March 2024 / Published: 27 March 2024 编译:松鼠哥 ...
作者强调了他们的工作对于未来设计和合成具有改进效力的 GS-6207 亚型的重要性,尽管目前的结果尚未达到预期的抗病毒效果。 信息来源:Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein Int. J. Mol. Sci. 2024, 25(7), 3734; https://doi.org/10.3390/ijms25073734 Submission...
More importantly, we have worked out a general synthetic route to allow the modular synthesis of novel GS-6207 subtypes. Significantly, the desired stereochemistry of the skeleton C2 was confirmed via an X-ray crystal structure of the key synthetic intermediate 22a. Although the newly synthesized ...