A. D. RogolSpringer Berlin HeidelbergRogol, AD Patterns of growth hormone release during childhood and adolescent development in the human. In: Touitou, Y, Haus, E eds. (1992) Biological Rhythms in Clinical and Laboratory Medicine. Springer-Verlag, New Yorkpp. 167...
Growth hormone therapy in childhood-onset growth hormone deficiency: adult anthropometric and psychological outcomes Sandberg DE, MacGillivray MH (2000) Growth hormone therapy in childhood-onset growth hormone deficiency: adult anthropometric and psychological outcomes. Endo- crine 12:173-182Sandberg DE, ...
The virtually unlimited availability of hGH manufactured by recombinant DNA technology raises a number of difficult questions with regard to the rational use of this material in the management of short stature in childhood. The theoretical limits of such use range from the restriction of GH therapy ...
In this Review, the authors chart the history of growth hormone, from discovery to clinical development and therapeutic approval, and discuss the emerging pathophysiology and treatment of its related growth disorders, particularly in childhood. Finally,
Growth hormone release is not continuous; it is released in a number of ‘bursts’ or pulses every three to five hours[13]. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones GH-releasing hormone (GHRH), which stimulates the pituitary...
Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adu... GH secretion was reevaluated after completion of GH treatment at a mean age of 19.2 +/- 3.2 yr in 35 young adults with childhood-...
Childhood-onset growth hormone (GH) deficiency in adult life Over the last decade GH replacement therapy for adults has progressed in status from research study to a mainstream clinical indication. An area ripe for f... CA Lissett,SM Shalet - 《Best Practice & Research Clinical Endocrinology &...
Disease caused by growth hormone deficiency and excess GH is vital for normal physical growth in children; its levels rise progressively during childhood and peak during the growth spurt that occurs in puberty, and declines from middle age onward. However, some individuals are affected by abnormaliti...
Ashley B. Grossman, in Growth Hormone Secretagogues, 1999 INTRODUCTION Growth hormone secretagogues (GHSs) release growth hormone (GH) via both the hypothalamus and the pituitary gland, and also stimulate ACTH and prolactin release. The presence of a seven transmembrane, G protein-coupled specific...
Achieving normal growth is one of the most challenging problems in the management of children with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (GH) promotes longitudinal growth and likely enables children with CKD and short stature to reach normal adult height. Here...