Wound repair requires close control of degradative and regenerative processes, involving numerous cell types and complex interactions between multiple biochemical cascades. Growth factors released in the traumatized area promote cell migration into the wound area (chemotaxis), stimulate the growth of ...
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The application of contemporary biochemical, analytical, and production technology have, in part, clarified the physiologic processes and identified many new factors active in wound repair. A restructuring of the sequence of the reparative events for the wound environment followed the identification of an...
source of growth factors and cytokines, which initiate the proliferative phase of wound repair. The latter starts with the migration and proliferation of keratinocytes at the wound edge and is followed by proliferation of dermal fibroblasts in the neighborhood of the wound. These cells subsequently...
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During the past few years, the availability of genetically modified mice has allowed elucidation of the function of various genes in the healing process, and these studies have shed light onto the role of growth factors, cytokines, and their downstream effectors in wound repair. This rev...
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Growth factors and cutaneous wound repair The healing of an adult skin lesion is a well studied but complex affair of some considerable clinical interest. Endogenous growth factors, including the E... P Martin,J Hopkinson-Woolley,J Mccluskey - 《Progress in Growth Factor Research》 被引量: 373...
Scientists at École Polytechnique Fédérale de Lausanne have greatly improved the effectiveness of clinical growth factors, paving new strategies for regenerative medicine. When we are wounded, our bodies naturally begin a process of repair of the damaged tissue. This process is mediated by ...