Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of the injured nerves requires a complex cellular and molecular response to rebuild the functional
Here we report that nerve growth factor receptor (NGFR) is upregulated in skeletal cells during OA and plays an essential role in the remodeling and repair of osteoarthritic joints. Specifically, NGFR is expressed in osteochondral cells but not in skeletal progenitor cells and induced by TNFα ...
Therefore, miR-31 may mediate apoptosis through this pathway to promote the repair of the body, which may become a potential therapeutic target for future diseases. View article Epigenetics in Exercise Science and Sports Medicine P.Zimmer, ...W.Bloch, inMedical Epigenetics, 2016 ...
Fibroblast growth factor (FGF) signaling encompasses a multitude of functions, including regulation of cell proliferation, differentiation, morphogenesis, and patterning. FGFs and their receptors (FGFR) are crucial for adult tissue repair processes. Aberrant FGF signal transduction is associated with various...
that Ctgf levels are increased in a Yes-associated protein (YAP)- dependent fashion in response to rapid, local H2O2 signaling generated by stressed mitochondria in the injured sciatic nerve, a finding highlighting the importance of signals triggered by mechanical force to motor nerve repair. Th...
The burden of type 1 diabetes (T1D) is enormous and is expected to increase. In 2021, there were about 8.4 million individuals worldwide living with T1D. The remaining life expectancy of a 10-year-old diagnosed with T1D ranges from a mean of 13 years in low-income countries to 65 yea...
To further assess the potential of these xanthone derivatives, we evaluated their invasion index based on invasion trough Geltrex-coated inserts. EGF was used as a positive control to stimulate cell migration. Every tested compound decreased cell motility, and thus wound repair and invasion (Figure ...
stimulated production of IGF-1 and poor growth. Serum GH concentrations are high because of the absence of the inhibitory action of IGF-1 on GH secretion. Dwarfism may also be caused by insensitivity of bone tissue and other tissues to IGF-1, resulting from decreased function of IGF-1 ...
ability to stimulate healthycell growthandrepair damaged tissues. It increases the availability of [...] healthkool.com healthkool.com 蘆薈能刺激健康細胞生長和修復受損的組織,它能增加皮膚的氧氣供應,從而幫助合成和增強皮膚組織。 healthkool.com
have also been investigated for their potential effects on cartilage regeneration. Statins are commonly used to lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA. However, they also have anti-inflammatory and antioxidant properties, which may benefit cartilage repair and regeneration. ...