Not long after the initial discovery of a green fluorescent protein from jellies, researchers were searching the oceans for additional colors of fluorescent proteins. One approach was to engineer the GFP so that
Drug Discovery TodayKain, S.R., 1999. Green fluorescent protein (GFP): applica- tions in cell-based assays for drug discovery. Drug Dis- cov. Today, 4(7):304-312. [doi:10.1016/S1359-6446(99) 01330-6]Kain,S.R.Green fluorescent protein (GFP): applica-tions in cell-based assays for...
Jane Liao and Allie C. Obermeyer explore the discovery, modification and applications of green fluorescent protein, best known for its use as a tool to cast light on cellular processes.
Correspondingly, the importance of GFP was recognized in 2008 when the Nobel Committee awarded Osamu Shimomura, Marty Chalfie, and Roger Tsien the Chemistry Nobel Prize "for the discovery and development of the green fluorescent protein, GFP." Why does GFP work so well in plants? Next to its...
In 2008, The Nobel Prize in Chemistry was awarded “for the discovery and development of the green fluorescent protein, GFP.” See Roger Tsien’s Nobel Prize lecture here. How does GFP work? GFP is a protein and, like other proteins, it can be expressed by living organisms. Once GFP is...
The Discovery of Aequorin and Green Fluorescent Protein. J. Microsc. 2005, 217, 3-15.O.SHIMOMURA. The discovery of aequorin and green fluorescent protein[J]. Journal of Microscopy . 2005 (1)Shimomura, O. The discovery of aequorin and green fluorescent protein. J Microsc 217, 1-15 ...
Shimomura, Chalfie, and Tsien were jointly awarded the Nobel Prize for Chemistry in 2008 for their discovery and development of the green fluorescent protein. GFP applications GFP has been widely adopted for microscopy-based research as it enables the visualization of proteins of interest with no ...
AmCyan1 fluorescent protein Takara Bio companies provide kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Biomedical Technology (Beijing) Co., Ltd. is part of a company ...
Natural proteins exhibit rich structural diversity based on the folds of an invariably linear chain. Macromolecular catenanes that cooperatively fold into a single domain do not belong to the current protein universe, and their design and synthesis open
Since the discovery that HIV Tat protein can penetrate mammalian cells and enter the nucleus11, hundreds of peptides that have the capacity to enter cells have been identified and, to various extents, characterised4. However, a thorough comparative investigation into the relative potential of differe...