The molecular adapter Grb14 is an inhibitor of insulin receptor (IR) catalytic activity, highly expressed in the liver. To study its involvement in hepatocyte proliferation we specifically inhibited its liver expression using an shRNA strategy in mice. Enhanced insulin signaling upon Grb14 ...
This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and ins ulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on ins ulin receptor signaling. ...
Metabolic diseases are characterized by a decreased action of insulin. During the course of the disease, usual treatments frequently fail and patients are finally submitted to insulinotherapy. There is thus a need for innovative therapeutic strategies to improve insulin action. Growth factor receptor-...
JW-E11344 rabbit Insulin,INS ELISA试剂盒 兔子胰岛素(INS)ELISA试剂盒96T/48T 国产/进口 JW-E08144 human Neuregulin 1,NRG-1 ELISA试剂盒 人神经调节蛋白1(NRG-1)ELISA试剂盒 96T/48T 国产/进口 JW-E10191 Rat High mobility group protein B1,HMGB-1 ELISA试剂盒大鼠高迁移率族蛋白B1(HMGB-1)ELISA试剂...
Adult Grb10:Grb14 double knockout (DKO) mice have the altered body composition characteristic of Grb10 KO mice, with glucose and insulin sensitivity further improved in comparison to either Grb10 KO or Grb14 KO single mutants, suggesting an additive effect of losing Insr inhibition from both ...
L’étude du niveau d’expression de Grb14 dans des modèles animaux d’insulinorésistance, ainsi que chez des patients diabétiques de type 2, a permis de mettre en évidence une corrélation inverse entre l’expression de Grb14 dans le tissu adipeux et la sensibilité à l’insuline. ...
Grb14 expression level in white adipose tissue is negatively correlated with insulin sensitivity .问题补充:匿名 2013-05-23 12:21:38 null 匿名 2013-05-23 12:23:18 圭亚那粮食局 14 表达水平的白色脂肪组织是负相关的胰岛素敏感度。 匿名 2013-05-23 12:24:58 Grb14表示水平在白色脂肪组织...
dominant role in Grb14 binding to the insulin receptor (IR), whereas the interaction between Grb7 and IRmainly involves the SH2 domain and that between Grb10 and IRinvolves both SH2 and PIR domains. For all three proteins, binding to IR results in the inhibition of insulin action. Grb14...
Growth factor receptor-bound protein 14 (Grb14) is a molecular adapter, highly expressed in liver, which binds to the activated insulin receptor and inhibits its tyrosine kinase activity. The physiological role of Grb14 in liver metabolism was unexplored. In this study we used RNA interference ...
et al. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14 . J. Biol. Chem. 277 , 4845–4852 (2002).Bereziat V., et al. 2002. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14 . J. Biol. Chem. 277 :4845–4852...