Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits1,2. The solution to this problem is to identify all causal genetic variants and to
Associated content Graph pangenome captures missing heritability and empowers tomato breeding Yao Zhou Zhiyang Zhang Sanwen Huang Nature Article Open Access 08 Jun 2022 Sections Figures References References Author information Ethics declarations Rights and permissions About this article AdvertisementNature...
Graph pangenome captures missing heritability and empowers tomato breeding. Nature. 2022;606:527–34. Article ADS CAS PubMed PubMed Central Google Scholar Li R, Gong M, Zhang X, Wang F, Liu Z, Zhang L, et al. A sheep pangenome reveals the spectrum of structural variations and their ...
BMC Bioinformatics (2023) 24:400 https://doi.org/10.1186/s12859-023-05531-6 BMC Bioinformatics RESEARCH Pan‑genome de Bruijn graph using the bidirectional FM‑index Lore Depuydt1*, Luca Renders1, Thomas Abeel2,3 and Jan Fostier1* Open Access *Correspondence: Lore.Depuy...
pggbhas been tested at scale in the Human Pangenome Reference Consortium (HPRC) as a method to build a graph from thedraft human pangenome. Documentation athttps://pggb.readthedocs.io/. citation Erik Garrison*,Andrea Guarracino*, Simon Heumos, Flavia Villani, Zhigui Bao, Lorenzo Tattini, ...
morphotype differentiation in peach. In this study, we constructed a graph pangenome for cultivated peach from sixteen individual peach genome assemblies. The graph pangenome contains 82.3 Mb of sequences that are absent in the reference HJML genome and captures abundant variations among these ...
graphtyper is a graph-based variant caller capable of genotyping population-scale short read data sets. It represents a reference genome and known variants of a genomic region using an acyclic graph structure (a "pangenome reference"), which high-throughput sequence reads are re-aligned to for ...
Structural variants (SVs) represent a major source of genetic diversity and are related to numerous agronomic traits and evolutionary events; however, their comprehensive identification and characterization in cucumber (Cucumis sativusL.) have been hindered by the lack of a high-quality pan-genome. He...
Zook , Tobias Marschall , Heng Li , Benedict Paten , Human Pangenome Reference Consortium Publication date (Electronic): May 10 2023 Journal: Nature Biotechnology Publisher: Springer Science and Business Media LLC Read this article at ScienceOpenPublisherPubMedFurther versions ...
Genome assembly structural variants graph-based pangenome PAV-based metabolomics-GWAS Introduction The wild potato is distributed across a broad geographic range (38°N–41°S latitude and 0–5,000 m altitude). It has more than 100 species with high morphological polymorphism, providing a sizeable...