For CR3022, a total of 12 mutants were picked out in the first-round experimental validation according to the ensemble prediction of their binding affinity changes against the RBDs of the wild-type, BA.1.1, and BA.4 SARS-CoV-2 strains. We note that the wild-type and Delta RBDs share ...
The complex functions of a living cell are conducted through the concerted activity of many genes and gene products. Much of the activity of a cell is organized into gene modules: sets of genes that are coregulated to respond to different conditions1. Gene modules have been widely studied in ...
As used herein, “stringent hybridization conditions” refers to hybridizing in 50% formamide at 5×SSC at a temperature of 42° C. and washing the filters in 0.2×SSC at 60° C. (1×SSC is 0.15M NaCl, 0.015M sodium citrate.) Stringent hybridization conditions also encompasses low ionic ...
The complex functions of a living cell are conducted through the concerted activity of many genes and gene products. Much of the activity of a cell is organized into gene modules: sets of genes that are coregulated to respond to different conditions1. Gene modules have been widely studied in...
A cutoff of 0.9 nm was used for Coulomb and van der Waals interactions. Long-range interactions were treated using the particle mesh Ewald method48 with a Fourier spacing of 0.12 nm. The velocity-rescaling thermostat49 was used with the temperature set to 300 K. Molecular dynamics ...
With the help of this easy-to-use open-source algorithm, much successful classification performance has been reported. A GCN architecture with one fewer convolutional layer than Altae’s classified the inhibitory activity of compounds against the human ether-a-go-go-related gene (hERG; a risk fa...
The complex functions of a living cell are conducted through the concerted activity of many genes and gene products. Much of the activity of a cell is organized into gene modules: sets of genes that are coregulated to respond to different conditions1. Gene modules have been widely studied in...
With the help of this easy-to-use open-source algorithm, much successful classification performance has been reported. A GCN architecture with one fewer convolutional layer than Altae’s classified the inhibitory activity of compounds against the human ether-a-go-go-related gene (hERG; a risk fa...