The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. ...
Medications and food are often taken together. Linking drug administration to a regular event like a meal can improve the patient’s adherence to the treatment regimen, especially in the elderly(1). However, concomitant drug and food intake create the opportunity for an interaction that may change...
The number of prescription drugs that can have serious adverse effects from interactions with grapefruit are markedly increasing, yet many physicians may be unaware of these effects, states an article published in CMAJ (Canadian Medical Association Journal). The article, a review by the researchers ...
Drug Interactions with Grapefruit Juice.Grapefruit juice sales are gradually increasing since 1970s and reached an average of 24.9 million litres per annum between 2004 and 2007. The use of grapefruit juice on its own or in a mixture with other juices is gradually increasing in UK and grape...
Grapefruit juice, known for its dangerous interactions with prescription drugs, improves a cancer drug outcome, scientists have found.
grapefruit, which may raise a potential issue of grapefruit-medication interactions in the South Korean market in the future, as has happened in the U... H Kim,House, Lisa A. - Meeting 被引量: 0发表: 2016年 Grapefruit juice–drug interactions The novel finding that grapefruit juice can...
e-drug interactions Grapefruit juice-drug interactionsGrapefruit juice-drug interactionsdoi:10.1111/j.1365-2125.2004.02305.xD.G.BaileyJ.M.O.ArnoldJ.D.SpenceingentaconnectBritish Journal of Clinical Pharmacology
Medications with innately low oral bioavailability because of substantial presystemic metabolism mediated by CYP3A4 appear affected by grapefruit juice. Clinically relevant interactions seem likely for most dihydropyridines, terfenadine, saquinavir, cyclosporin, midazolam, triazolam and verapamil and may also ...
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Now that we’ve sung grapefruit’s praises, it’s time to tackle that unfortunate problem of unwanted grapefruit-medication interactions. To give you a sense of the scope of the issue, check out thisfour-page list of pharmaceuticalswith known grapefruit interactions. ...