PMS2, a gene responsible for Lynch syndrome, previously referred to as hereditary non-polyposis colorectal cancer, was mutated in this case of granulosa cell tumor. Although granulosa cell tumor is not a pathognomonic malignancy of Lynch syndrome, it has been found in 2/74 ovarian cancers in ...
Stable activation of the WNT signaling effector β-catenin (CTNNB1) in granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life or following targeted deletion of the tumor suppressor gene Pten. Conversely, expression ...