All of them had typical granulomas on the biopsy specimens, indicating that the expected impairment of granuloma formation is not always the case. The notion of granuloma-free TB in patients receiving anti-TNF therapy could shift a clinician's path away from performing a biopsy, thus delaying ...
Tuberculosis (TB) is responsible for death of nearly two million people in the world annually. Upon infection, Mycobacterium tuberculosis (Mtb) causes formation of granuloma where the pathogen goes into dormant state and can live for decades before resuscitation to develop active disease when the imm...
In latent TB infection, humans can harbor a small number of dormant Mtb bacilli that are likely contained in microgranuloma. These organisms are viable but in a dormant state. Animal models have been used to study various aspects of granuloma formation, dormancy and the host-pat...
Granuloma formation in the liver of mice infected with BCG coincides with local TNF synthesis. Injection of rabbit anti-TNF antibody, after 1 or 2 weeks of infection, dramatically interferes with the development of granulomas (both in number and size, large epithelioid cells failing to appear) ...
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells. Although ectopic lymphoid tissue formation is associated with many autoimmune diseases, it is unclear whether it serves a functional role in autoimmune res... JS Wei...
Ronald B. Johnston MD, in Weedon's Skin Pathology Essentials (Second Edition), 2017 Foreign body granulomas NamePredilection and Clinical Key FeaturesHistopathology Exogenous material • Foreign body granuloma formation around starch, talc, tattoo material, suture, wood splinters, pencil lead, glass ...
Tuberculosis (TB) granulomas are compact, organized agglomerations of infected and uninfected macrophages, T cells, neutrophils, and other immune cells. Wi
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationships that control human granulomas is limited. Here, we used mu...
Bovine tuberculosis still represents a universal threat that creates a wider range of public and animal health impacts. One of the most important steps in the pathogenesis of this disease and granuloma formation is the phagocytosis of tuberculous bacilli
Sarcoidosis is a multisystem granulomatous disease characterized by the development of noncaseating epithelioid cell granulomas with no apparent cause. While the suspicion is that an infectious pathogen is a trigger for granuloma formation in sarcoidosis, a causative antigen remains unidentified despite ext...