In particular, we published several agent-based models (ABMs) of granuloma formation in TB that include many subtypes of T cell populations, macrophages as well as key cytokine and chemokine effector molecules. These ABM studies emphasize the important role of T-cell related mechanisms in ...
In latent TB infection, humans can harbor a small number of dormant Mtb bacilli that are likely contained in microgranuloma. These organisms are viable but in a dormant state. Animal models have been used to study various aspects of granuloma formation, dormancy and the host-pat...
Granuloma formation in the liver of mice infected with BCG coincides with local TNF synthesis. Injection of rabbit anti-TNF antibody, after 1 or 2 weeks of infection, dramatically interferes with the development of granulomas (both in number and size, large epithelioid cells failing to appear) ...
Yet, Th1 cells are the crucial driving forces of granuloma formation and maintenance in most granulomatous diseases, including berylliosis, sarcoidosis and TB. The term TB was coined for the first time by Lukas Schönlein in the mid-19th century when he classified different forms of diseases ...
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationships that control human granulomas is limited. Here, we used mu...
Tuberculosis (TB) granulomas are compact, organized agglomerations of infected and uninfected macrophages, T cells, neutrophils, and other immune cells. Wi
Tuberculosis and granuloma formation in patients receiving anti-TNF therapy. In patients receiving anti-() therapy, a probable exacerbation of (TB) is a major adverse event. The impairment of differentiation is considered a characte... A Iliopoulos,K Psathakis,S Aslanidis,... - 《International ...
Further luminal growth caused the crystals to become lodged at some point in the nephron, distort and destroy tubule cells, and pierce through basement membranes with subsequent exposure to interstitial monocytes and formation of granulomas. It is likely these morphological abnormalities evolve from ...
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56, 731–740 (1989). Article CAS PubMed Google Scholar Roach, D.R. et al. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of...
Although hepatic granulomas are common, clinically significant liver disease is unusual (6.7% of cases), manifested byportal hypertension,esophagogastric varices, and rarely, jaundice. The infrequent case of portal hypertension is secondary to significant portal fibrosis and granuloma formation in the po...