All of them had typical granulomas on the biopsy specimens, indicating that the expected impairment of granuloma formation is not always the case. The notion of granuloma-free TB in patients receiving anti-TNF therapy could shift a clinician's path away from performing a biopsy, thus delaying ...
Granuloma formation in the liver of mice infected with BCG coincides with local TNF synthesis. Injection of rabbit anti-TNF antibody, after 1 or 2 weeks of infection, dramatically interferes with the development of granulomas (both in number and size, large epithelioid cells failing to appear) ...
Tuberculosis (TB) is responsible for death of nearly two million people in the world annually. Upon infection, Mycobacterium tuberculosis (Mtb) causes formation of granuloma where the pathogen goes into dormant state and can live for decades before resuscitation to develop active disease when the imm...
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationships that control human granulomas is limited. Here, we used mu...
Yet, Th1 cells are the crucial driving forces of granuloma formation and maintenance in most granulomatous diseases, including berylliosis, sarcoidosis and TB. The term TB was coined for the first time by Lukas Schönlein in the mid-19th century when he classified different forms of diseases ...
In this study, we assessed circulating levels of NET degradation products in patients with distinct types of TB. We report increased circulatory NET formation in TB patients in relapse, and TB patients with extensive tissue damage, thus highlighting the importance of balancing NET formation to preven...
Inschistosomiasis, progressive portal scarring (pipestem fibrosis) is typical; liver function is usually preserved, but marked splenomegaly and variceal hemorrhage can occur. Key Points Hepatic granulomas can result from many medications and systemic disorders; primary liver disorders are unco...
Tuberculosis (TB) granulomas are compact, organized agglomerations of infected and uninfected macrophages, T cells, neutrophils, and other immune cells. Wi
We thank C. de Chastellier and J.-F. Emile for the electron microscopy and histology inFigures 1and3. Supported by the European Union Framework Programme (Consortiums StopLATENT-TB Health-2007-200999 to P.-J.C.), the Bill and Melinda Gates Foundation Grand Challenges in Global Health (D...
Although hepatic granulomas are common, clinically significant liver disease is unusual (6.7% of cases), manifested byportal hypertension,esophagogastric varices, and rarely, jaundice. The infrequent case of portal hypertension is secondary to significant portal fibrosis and granuloma formation in the po...