Granulocytes are immune cells with granules containing enzymes that are released during infections, as well as inallergicreactions andasthma, causing the symptoms associated with these conditions. The four types of granulocytes are neutrophils, basophils, mast cells, and eosinophils. Granulocytes engulf th...
Neutrophilic granulocytes (neutrophils) are the most abundant leukocytes in human blood and play a central role in the innate immune response [1]. This issue follows mature neutrophils through their various aspects in medical therapies as well as through immunological interactions against them that ...
Biochemical detection of neutrophils in peritoneal effluents by Cytur-test has been advocated as a fast and reliable bedside test when peritonitis is suspected in patients on continuous ambulatory peritoneal dialysis. The Cytur-test developed a light blue colour when the neutrophil count exceeded 108 ...
A critical point during the course of bacterial meningitis is the excessive influx of polymorphnuclear neutrophils (PMNs) from the blood into the brain. Both paracellular and transcellular routes of leukocyte transmigration through the blood-brain barrier have been described in CNS diseases so far. Th...
Admittedly, RT-PCR does not allow to quantify the strength of expression, particularly not in cells in their final state of differentiation such as neutrophils. Nevertheless, these ex- periments prompted us to seek evidence for the functional expression of TRPM2. The functional hallmark of TRPM2...
Ideally the erythrocytes should be removed as soon as possible after drawing but the subsequent gradient separation of the mononuclear cells and PMNs can be carried out up to 6 h later. 2. If the density of this cushion is 1.090 g/ml, a small percentage of the neutrophils and most of ...
Cre recombinase and tdTomato expressed from a neutrophil-specific promoter allow highly specific genetic manipulation and labeling of neutrophils. Neutrophil granulocyte biology is a central issue of immunological research, but the lack of animal models
Daniel Petersheim, Yanxin Fan, Ehsan Bahrami, Tomas Racek, Meino Rohlfs, Jacek Puchałka, Christian Mertes, Julien Gagneur, Christoph Ziegenhain, Wolfgang Enard, Asbjørg Stray-Pedersen, Peter D Arkwright, Miguel R Abboud, Vahid Pazhakh, ...
18 Recent imaging studies that tracked the migration of neutrophils to the lungs, before homing to the bone marrow, suggest a much longer lifespan of several days.26 This raises potential concerns that transfected granulocytes may gravitate to the lungs following infusion and cause pulmonary ...
4I and K), as also suggested by their lower transcript levels compared to SLE (Fig. 4A). These data do not prove that ZBP1 is the nucleic acid sensor that detects L1 ORF2p products in SLE neutrophils, but it seems more likely than cGAS because it co-localizes with ORF1p granules ...