McGinn and colleagues48 evaluated compliance with an evidence-based clinical decision support tool integrated into their EHR for streptococcal pharyngitis and pneumonia. Through their EHR, they were able to determine the frequency with which the tool was used and subsequently found that antibiotic use ...
pneumonia 31158 Fractional Inhibitory Concentration Index with Tobramycin 0.25 (0.125,0.125) Gentamicin 0.37 (0.125,0.25) Gatifloxacin 0.56 (0.06,0.5) Chloramphenicol 0.38 (0.13,0.25) 0.75 (0.5,0.25) 0.25 (0.125,0.125) 0.75 (0.25,0.5) 0.31 (0.25,0.06) 0.63 (0.13,0.5) 0.56 (0.06,0.5) 0.38 (...
baumannii pneumonia model, whereas rifampin alone had only a modest efficacy [72]. Strains of Enterobacteriaceae seldomly cause complicated skin and soft tissue infections (cSSI). However, the neutropenic murine thigh infection model (representing cSSI) is widely used in pharmacokinetic/pharmacodynamic (...
Review The Mechanisms of Virulence Regulation by Small Noncoding RNAs in Low GC Gram-Positive Pathogens Stephanie Pitman and Kyu Hong Cho * Received: 16 November 2015; Accepted: 4 December 2015; Published: 14 December 2015 Academic Editor: Mark Richter Department of Biology, Indiana State ...
pneumonia H. pylori P. aeruginosa V. cholera N. meningitidis Encoded by Core genome Core genome Core genome Core genome Core genome Core genome Core genome Core genome Genetic island Sites of PEA Modification Lipid A headgroups Lipid A headgroups Lipid A headgroups Lipid A headgroups Lipid A ...
This is distinct from the gram-positive bacteria which have a thick peptidoglycan cell wall. Gram-negative bacteria are ubiquitous in nature and cause infection in multiple body sites including the urinary tract, lower respiratory tract, biliary tract, and bloodstream, among others. Due in large ...
The peptide also demonstrated in vivo activity in urinary tract infection (UTI) and pneumonia mouse models [16]. Cytotoxicity and haemolysis assays were performed for arenicin-3 derivatives using HEK293 cells and human red blood cells, respectively [16]. The peptides did not display haemolytic ...